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Genomic Architecture of Functional Brain Networks in PTSD

Award Number: R01MH111671
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/06/2017
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Genomic Architecture of Functional Brain Networks in PTSD - ABSTRACT Our overarching goal is to investigate the genetic architecture of canonical functional resting-state networks (RSN) in PTSD. The disruption of several canonical RSNs including the default mode network (DMN), ventral attention network (VAN), and salience network (SN) are strongly implicated in posttraumatic stress disorder (PTSD). These RSN alterations are associated with specific symptom clusters of PTSD (e.g. intrusive re-experiencing symptoms). Canonical RSN connectivity and regional amplitude of BOLD signal, which are associated with PTSD and its symptom dimensions, constitute highly heritable phenotypes (h2 = 0.4 – 0.6) that exceed the heritability of task-based fMRI and the majority of structural neuroimaging phenotypes. A genetic vulnerability to developing PTSD following exposure to trauma has long been hypothesized and is now supported by evidence. Discovery of the genetic factors involved in brain communication and brain connectivity that contribute to PTSD may prove vital to new treatment breakthroughs. The coupling of brain connectivity with its genetic architecture, mapping the neurogenetic pathways of PTSD, and new knowledge of neural and genetic mechanisms will support precision-medicine guided drug discovery for managing mental illnesses that follow psychological trauma. Our aims are to 1: Investigate differences in the genetic architecture of functional connectomics associated with PTSD. 2: Investigate the role of PTSD on the relationship between the genetic architecture of brain structure and functional connectomics. 3: Investigate the effects of PTSD on the link between gene transcription architecture and functional connectomics. The coupling of cortical functional connectomics with its genetic architecture and its transcriptional architecture in relation to known disruptions of functional connectomics in PTSD may offer exciting opportunities to discover targeted therapies. Mapping the neurogenetic pathways of PTSD to the severity of PTSD symptoms will also be critical to the future design, development, and selection of yet undiscovered treatments. Knowledge of their unique neural and genetic mechanisms will be vital to precision-medicine guided drug discovery for managing mental illnesses that may follow psychological trauma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $656,590 )
2026	2026	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	8	2/10/2026	NON-COMPETING CONTINUATION	$656,590
														Subtotal = $656,590

Issue Date FY: 2025 ( Subtotal = $558,102 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	7	12/19/2024	NON-COMPETING CONTINUATION	$558,102
2025	2020	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	001	4	1/10/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $558,102

Issue Date FY: 2024 ( Subtotal = $652,881 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	004	6	8/14/2024	NON-COMPETING CONTINUATION	$65,660
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	003	6	1/29/2024	NON-COMPETING CONTINUATION	$590,930
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	002	5	1/12/2024	COMPETING CONTINUATION	-$3,709
2024	2018	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	001	2	1/11/2024	NON-COMPETING CONTINUATION	$0
2024	2017	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	1	1/11/2024	NEW	$0
														Subtotal = $652,881

Issue Date FY: 2023 ( Subtotal = $690,799 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Mental Health Research Grants	000	5	1/31/2023	COMPETING CONTINUATION	$690,799
														Subtotal = $690,799

Issue Date FY: 2020 ( Subtotal = $459,250 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	002	4	8/7/2020	NON-COMPETING CONTINUATION	$459,250
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	003	4	8/19/2020	NON-COMPETING CONTINUATION	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	3	11/19/2019	NON-COMPETING CONTINUATION	$0
2020	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	001	3	3/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $459,250

Issue Date FY: 2019 ( Subtotal = $446,914 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	3	7/8/2019	NON-COMPETING CONTINUATION	$446,914
														Subtotal = $446,914

Issue Date FY: 2018 ( Subtotal = $377,817 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	001	2	8/30/2018	NON-COMPETING CONTINUATION	$459,764
2018	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	1	8/16/2018	NEW	-$81,947
														Subtotal = $377,817

Issue Date FY: 2017 ( Subtotal = $552,639 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Mental Health Research Grants	000	1	9/6/2017	NEW	$552,639
														Subtotal = $552,639

Grand Total All Awards = $4,394,992

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Genomic Architecture of Functional Brain Networks in PTSD

Award Number: R01MH111671

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/06/2017

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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