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Novel Developmental Pathways Underlying Psychiatric Disorders

Award Number: R01MH110438
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2016
PERIOD OF PERFORMANCE END DATE: 12/31/2026

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Novel Developmental Pathways Underlying Psychiatric Disorders - Abstract The central nervous system (CNS) acquires its vasculature by angiogenesis, a process that is critical for its development and repair. Our findings have offered new perspectives on intrinsic regulation of angiogenesis and highlighted the importance of vascular diversity during brain development. Pre-formed vascular networks act as a template for the formation of the neocortex. They are strategically positioned, spatially and temporally to provide support and critical guidance cues to instruct key events of brain development. Recently, our studies uncovered a novel GABA signaling pathway in embryonic forebrain endothelial cells that works independently from neuronal GABA signaling. It revealed that disruptions in endothelial GABA signaling from early embryonic stages can directly contribute to the origin of psychiatric disorders including autism, epilepsy, schizophrenia, anxiety and depression. This vascular GABA signaling pathway extends into the postnatal phase with added complexities. Therefore, our renewal application will examine the key fundamental mechanisms of action of endothelial GABAA receptor-GABA signaling components during the postnatal period with new significance for neocortical development and disease. It aims at highlighting hitherto unknown mechanisms of endothelial GABA’s role in vascular regression and stabilization. It explores the novel concept that endothelial GABA components are indispensable for postnatal brain development and can differentially shape blood flow. Results will uncover fundamental mechanisms governing postnatal angiogenesis, offer new perspectives on the cellular and molecular landscape of the developing neocortex and will lead to discoveries with unprecedented implications for understanding and treatment of several neuropsychiatric illnesses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $445,683 )
2025	2025	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	000	9	12/13/2024	NON-COMPETING CONTINUATION	$445,683
														Subtotal = $445,683

Issue Date FY: 2024 ( Subtotal = $532,759 )
2024	2024	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	001	8	8/14/2024	NON-COMPETING CONTINUATION	$53,276
2024	2024	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	000	8	1/5/2024	NON-COMPETING CONTINUATION	$479,483
														Subtotal = $532,759

Issue Date FY: 2023 ( Subtotal = $532,759 )
2023	2023	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	002	7	3/3/2023	NON-COMPETING CONTINUATION	$532,759
2023	2022	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	001	6	12/5/2022	COMPETING CONTINUATION	$43
2023	2020	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	000	5	12/5/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$43
														Subtotal = $532,759

Issue Date FY: 2022 ( Subtotal = $547,509 )
2022	2022	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	002	6	6/27/2022	COMPETING CONTINUATION	$53,277
2022	2022	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	001	6	3/4/2022	COMPETING CONTINUATION	$494,232
2022	2020	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	000	5	3/1/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $547,509

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	001	5	6/13/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$16,344
2021	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	4	6/13/2021	NON-COMPETING CONTINUATION	-$16,344
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $385,576 )
2020	2020	HUNTINGTON MEDICAL RESEARCH INSTITUTES	686 S FAIR OAKS AVE	PASADENA	CA	91105	LOS ANGELES	USA	Mental Health Research Grants	001	5	6/17/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$385,576
2020	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	4	6/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $385,576

Issue Date FY: 2019 ( Subtotal = $410,483 )
2019	2019	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	4	5/14/2019	NON-COMPETING CONTINUATION	$410,483
														Subtotal = $410,483

Issue Date FY: 2018 ( Subtotal = $411,361 )
2018	2018	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	3	5/14/2018	NON-COMPETING CONTINUATION	$411,361
														Subtotal = $411,361

Issue Date FY: 2017 ( Subtotal = $416,345 )
2017	2017	MCLEAN HOSPITAL CORPORATION, THE	115 MILL ST	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	2	5/18/2017	NON-COMPETING CONTINUATION	$416,345
														Subtotal = $416,345

Issue Date FY: 2016 ( Subtotal = $412,946 )
2016	2016	MCLEAN HOSPITAL	115 MILL STREET	BELMONT	MA	02478	MIDDLESEX	USA	Mental Health Research Grants	000	1	8/31/2016	NEW	$412,946
														Subtotal = $412,946

Grand Total All Awards = $4,095,421

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Novel Developmental Pathways Underlying Psychiatric Disorders

Award Number: R01MH110438

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2016

PERIOD OF PERFORMANCE END DATE: 12/31/2026

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