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Autism Genetics Phase II: Increasing Representation of Human Diversity

Award Number: R01MH100027
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/25/2013
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Autism Genetics Phase II: Increasing Representation of Human Diversity - Abstract Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder whose genetic contributions are increasingly recognized. However, the vast majority of genetic research and discovery has occurred in populations of European (EU) origin, significantly underrepresenting communities of color and those of self- described African American (AA) ancestry. This disparity in genetics research, coupled with disparities in diagnosis and treatment, motivated the investigators in this Network to take a major new direction in their research, embarking on what has been a unique and highly successful recruitment of AA families with ASD (AA-ASD) into gene discovery research at multiple sites, conducted phenotyping—including information of critical relevance to the elucidation of race-based health disparities—while commencing genetic analysis to identify ASD susceptibility genes. Via this collaborative effort, we aim to fill significant gaps in ASD research by continuing to recruit and perform genetic research in this important population that has not previously been well represented in ASD genetics research. Our Network involves seven research sites and a DCC, collaborating in a systematic investigation of ASD genetics in order to identify rare mutations, chromosomal abnormalities, and common variation contributing to ASD susceptibility in the AA population, while leveraging this unique opportunity to understand and potentially remediate health disparities. Specifically, we will enrich existing resources by recruiting at least 720 AA probands and additional family members to ascertain a cohort of at least 2000 probands in total. Our recruitment plan includes an embedded health disparities project that continues to evaluate access and quality of care for AAs with ASD while increasing participation of AA individuals in genetic research. We will conduct whole-genome sequencing (WGS), which permits comprehensive investigation of genome-wide structural variation (SV) and coding and non-coding sequence variation (SNV) in ASD. We will employ novel methods to define the ancestral origin of specific chromosomal segments and ascertain the background on which susceptibility alleles occur and relate these features to quantitative phenotypes. In parallel, gene expression profiling and network analysis will be used to prioritize variants. Genetic risk factors identified in the mostly EU samples will be tested for association in the AA sample to determine whether these cohorts share the same genetic risk factors, using a sample size providing power to replicate previous associations and to identify rare, recurrent CNV and SNV. We will use local ancestry to boost power of polygenic risk scores derived from EU cohorts. The observation of new forms or different population frequencies of ASD-related variation in this sample as well as the sharing of most CNV and SNV with other cohorts are both outcomes that will have great significance for future studies and for clinical care. As has been our practice, our Network will make all phenotypic and genotype data accessible via the internet on a rolling basis, further enhancing the value of this resource to the community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,310,531 )
2024	2024	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	002	17	8/16/2024	NON-COMPETING CONTINUATION	$2,310,531
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	16	6/25/2024	COMPETING CONTINUATION	$635,690
2024	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	15	6/25/2024	NON-COMPETING CONTINUATION	-$635,690
														Subtotal = $2,310,531

Issue Date FY: 2023 ( Subtotal = $2,237,468 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	002	16	7/28/2023	COMPETING CONTINUATION	$8,730
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	16	7/5/2023	COMPETING CONTINUATION	$2,424,976
2023	2016	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	9	10/1/2022	SUPPLEMENT FOR EXPANSION	-$196,238
														Subtotal = $2,237,468

Issue Date FY: 2022 ( Subtotal = $2,356,375 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	15	4/25/2022	NON-COMPETING CONTINUATION	$2,356,375
														Subtotal = $2,356,375

Issue Date FY: 2021 ( Subtotal = $2,759,301 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	14	3/17/2021	NON-COMPETING CONTINUATION	$2,759,301
2021	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	002	11	8/18/2021	COMPETING CONTINUATION	-$196,238
2021	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	10	8/18/2021	NON-COMPETING CONTINUATION	$196,238
														Subtotal = $2,759,301

Issue Date FY: 2020 ( Subtotal = $4,042,577 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	13	5/19/2020	NON-COMPETING CONTINUATION	$2,750,081
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	002	13	6/17/2020	NON-COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	11	3/30/2020	COMPETING CONTINUATION	$1,292,496
														Subtotal = $4,042,577

Issue Date FY: 2019 ( Subtotal = $2,699,155 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	12	8/6/2019	SUPPLEMENT FOR EXPANSION	$396,374
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	12	4/16/2019	NON-COMPETING CONTINUATION	$2,302,781
														Subtotal = $2,699,155

Issue Date FY: 2018 ( Subtotal = $1,113,495 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	004	11	6/29/2018	COMPETING CONTINUATION	$17,806
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	003	11	6/28/2018	COMPETING CONTINUATION	$2,388,185
2018	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	10	3/27/2018	NON-COMPETING CONTINUATION	$1,444
2018	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	002	10	6/22/2018	NON-COMPETING CONTINUATION	-$1,292,496
2018	2015	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	8	3/27/2018	NON-COMPETING CONTINUATION	-$1,444
														Subtotal = $1,113,495

Issue Date FY: 2017 ( Subtotal = $2,759,584 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	10	7/19/2017	NON-COMPETING CONTINUATION	$275,959
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	10	2/28/2017	NON-COMPETING CONTINUATION	$2,483,625
														Subtotal = $2,759,584

Issue Date FY: 2016 ( Subtotal = $2,653,574 )
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	9	8/25/2016	SUPPLEMENT FOR EXPANSION	$154,793
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	9	4/12/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,498,781
														Subtotal = $2,653,574

Issue Date FY: 2015 ( Subtotal = $2,715,972 )
2015	2015	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	8	3/16/2015	NON-COMPETING CONTINUATION	$2,715,972
														Subtotal = $2,715,972

Issue Date FY: 2014 ( Subtotal = $2,728,166 )
2014	2014	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	7	6/2/2014	NON-COMPETING CONTINUATION	$2,728,166
														Subtotal = $2,728,166

Issue Date FY: 2013 ( Subtotal = $3,168,451 )
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	6	8/6/2013	SUPPLEMENT FOR EXPANSION	$162,535
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	6	3/25/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$3,005,916
														Subtotal = $3,168,451

Grand Total All Awards = $31,544,649

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Autism Genetics Phase II: Increasing Representation of Human Diversity

Award Number: R01MH100027

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/25/2013

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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