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Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving Adversities

Award Number: R01MH091864
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Children with severe Early Caregiving Adversities (ECAs) are the most vulnerable to psychopathology as a result of prolonged neglect, abuse, and care disruptions that impact neurodevelopment. It is currently estimated that addressing ECAs would lead to a 29.8% reduction in worldwide psychiatric illness. Existing research, including findings from the original grant of this renewal, has demonstrated that there is a very strong link between ECA exposures and increased risk for psychopathology and altered neurodevelopment at the population level; and yet, given the heterogeneity in ECA populations, there is a critical gap in knowledge regarding how ECAs increase any specific risks to an individual child. The proposed research addresses this significant mental health problem by combining sophisitcated data-analysis methods that use experiential and phenotypic heterogeneity together with longitudinal neuroimaging and behavioral assessments in school-age children. This approach will increase precision when linking ECAs and child outcomes associated with the Research Domain Criteria constructs of Negative Valence and Cognitive Control Systems (NVS/CCS). The overarching goal of the present work is to create an explanatory model for the heterogeneous impact of ECAs on neurodevelopmental trajectories of NVS/CCS. This project's premise is that children exposed to ECAs have highly heterogeneous developmental histories as well as heterogeneous outcomes; therefore, prediction of ECA outcomes requires cutting-edge, sophisticated data analytic methods. We hypothesize that data-driven approaches will 1) more precisely define NVS/CCS outcomes for school-aged children with ECAs, and 2) provide a more robust explanatory model for links between ECAs and NVS/CCS trajectories. Aim 1A subtypes children with a history of ECAs based on 2.5-year developmental trajectories of NVS/CCS. 300 6-8 year old children (250 sampled from previous institutional and foster care; 50 community comparisons) will provide neuroimaging, behavioral, and self/caregiver reports every 15 months for 2.5 years. Biclustering methods will be applied to the baseline and follow-up data to identify homogeneous NVS/CCS final outcome clusters of children. Aim 1B develops an explanatory model to predict developmental trajectory subtypes for children with ECAs, from early life profiles and brain/behavior phenotypes at the time of enrollment. Machine learning methods applied to early life profiles, baseline NVS/CCS profiles, and sex, will predict developmental trajectory subtypes. Aim 2 identifies adverse and protective life events during the 2.5-year assessment period that are predictive of 2.5-year follow-up outcomes for children with ECAs. The inclusion of child-sex and current life- events will identify potential divergence in pathways across middle childhood. This prospective design of children exposed to various ECAs is designed to develop predictive models for ECA trajectory subtypes and outcomes, which can inform our understanding of risk and protective factors in accord with the goals of precision medicine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$12 )
2025	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	10	10/21/2024	SUPPLEMENT FOR EXPANSION	-$12
														Subtotal = -$12

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	001	10	9/1/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	10	7/25/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $439,843 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	10	8/29/2022	SUPPLEMENT FOR EXPANSION	$439,843
														Subtotal = $439,843

Issue Date FY: 2021 ( Subtotal = $411,713 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	001	10	6/9/2021	NON-COMPETING CONTINUATION	$411,713
2021	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	9	6/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $411,713

Issue Date FY: 2020 ( Subtotal = $698,273 )
2020	2020	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	9	6/26/2020	NON-COMPETING CONTINUATION	$698,273
														Subtotal = $698,273

Issue Date FY: 2019 ( Subtotal = $736,672 )
2019	2019	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	8	6/25/2019	NON-COMPETING CONTINUATION	$736,672
														Subtotal = $736,672

Issue Date FY: 2018 ( Subtotal = $753,980 )
2018	2018	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	7	6/25/2018	NON-COMPETING CONTINUATION	$753,980
														Subtotal = $753,980

Issue Date FY: 2017 ( Subtotal = $782,745 )
2017	2017	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Mental Health Research Grants	000	6	8/29/2017	COMPETING CONTINUATION	$782,745
														Subtotal = $782,745

Issue Date FY: 2014 ( Subtotal = $266,805 )
2014	2014	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	5	5/21/2014	NON-COMPETING CONTINUATION	$266,805
														Subtotal = $266,805

Issue Date FY: 2013 ( Subtotal = $256,133 )
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	4	5/10/2013	NON-COMPETING CONTINUATION	$256,133
														Subtotal = $256,133

Issue Date FY: 2012 ( Subtotal = $266,805 )
2012	2012	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	3	4/28/2012	NON-COMPETING CONTINUATION	$266,805
														Subtotal = $266,805

Issue Date FY: 2011 ( Subtotal = $266,805 )
2011	2011	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	2	6/15/2011	NON-COMPETING CONTINUATION	$266,805
														Subtotal = $266,805

Issue Date FY: 2010 ( Subtotal = $269,500 )
2010	2010	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	1	8/30/2010	NEW	$269,500
														Subtotal = $269,500

Grand Total All Awards = $5,149,262

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Predicting Heterogeneous Neurodevelopmental Outcomes in School-age Children with Early Caregiving Adversities

Award Number: R01MH091864

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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