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Developmental Pathways to Borderline Personality Disorder: Longitudinal Observational, Clinical, and Neural Predictors From Early Childhood to Young Adulthood

Award Number: R01MH090786
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2010
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Developmental Pathways to Borderline Personality Disorder: Longitudinal Observational, Clinical, and Neural Predictors From Early Childhood to Young Adulthood - PROJECT SUMMARY Borderline Personality Disorder (BPD) is a prominent contributor to disability, burden, and increased mortality. Although impairments in self (RDoC Systems for Social Processes: Perception and understanding of self) and interpersonal (RDoC Systems for Social Processes: Affiliation) functioning originate in early childhood, little is known about the developmental psychopathology of these core features in BPD, as opposed to a related psychiatric disorder that often precedes and co-develops with BPD: Major Depressive Disorder (MDD). The current proposal will establish developmental trajectories of interpersonal and self dysfunction from early childhood into young adulthood, examining interactions with environmental factors and associations with aberrant neural circuitry, to predict onset of BPD in early adulthood. In this renewal, we leverage 17 years of previously collected longitudinal data (R01 MH090786) from 348 young children enriched for emotional dysregulation. Now young adults (19-25 years), 36% exhibit BPD above diagnostic threshold. This sample offers an unparalleled opportunity to understand specific developmental precursors for BPD onset. Rich phenotyping, including over a decade of clinical interviews, narratives, questionnaires, observations, and repeated MRI and EEG assessments make this the ideal and highly cost-effective dataset to investigate impairments in self and interpersonal functioning that lead to BPD versus MDD. New data collection in young adulthood includes multi-method assessments of interpersonal and self functioning alongside psychiatric diagnostic interviews. Our motivating hypothesis is that in the context of emotion dysregulation, peer acceptance and aggression (interpersonal dysfunction) from preschool through middle childhood, interacts with self-functioning (unstable, incoherent self-worth and self- concept) in adolescence to uniquely predict BPD onset in adulthood versus MDD. We will examine: (1) how specific aspects of these constructs prospectively relate to adult BPD, as opposed to continuation of MDD; (2) during which developmental periods these constructs provide the most predictive utility, including the moderating effect of specific environmental factors; and (3) assess the predictive and mechanistic role of neural correlates of these constructs in forecasting BPD versus MDD. Findings will inform the optimal timing and content-focus (i.e., specific neural/behavioral self and interpersonal targets) of novel early-intervention for preventing BPD during the earliest developmental periods. This longitudinal research will be able to identify risk factors for the persistence or worsening of interpersonal and self dysfunction and BPD onset, offering the best starting point toward developing a prevention strategy for BPD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $624,218 )
2025	2025	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	13	4/12/2025	NON-COMPETING CONTINUATION	$624,218
														Subtotal = $624,218

Issue Date FY: 2024 ( Subtotal = $756,298 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	12	5/21/2024	NON-COMPETING CONTINUATION	$756,298
														Subtotal = $756,298

Issue Date FY: 2023 ( Subtotal = $791,166 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	11	7/12/2023	COMPETING CONTINUATION	$791,166
														Subtotal = $791,166

Issue Date FY: 2021 ( Subtotal = -$68,811 )
2021	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	10	9/23/2021	NON-COMPETING CONTINUATION	-$68,811
														Subtotal = -$68,811

Issue Date FY: 2019 ( Subtotal = $713,642 )
2019	2019	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	10	5/15/2019	NON-COMPETING CONTINUATION	$713,642
														Subtotal = $713,642

Issue Date FY: 2018 ( Subtotal = $950,796 )
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	002	9	6/15/2018	NON-COMPETING CONTINUATION	$91,129
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	8	11/17/2017	SUPPLEMENT FOR EXPANSION	$39,520
2018	2018	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	001	9	3/12/2018	NON-COMPETING CONTINUATION	$820,147
														Subtotal = $950,796

Issue Date FY: 2017 ( Subtotal = $1,048,325 )
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	000	8	3/31/2017	NON-COMPETING CONTINUATION	$768,901
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	001	8	6/10/2017	SUPPLEMENT FOR EXPANSION	$193,989
2017	2017	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Mental Health Research Grants	002	8	7/30/2017	NON-COMPETING CONTINUATION	$85,435
														Subtotal = $1,048,325

Issue Date FY: 2016 ( Subtotal = $859,112 )
2016	2016	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	7	3/15/2016	NON-COMPETING CONTINUATION	$859,112
														Subtotal = $859,112

Issue Date FY: 2015 ( Subtotal = $1,146,567 )
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	001	6	8/1/2015	SUPPLEMENT FOR EXPANSION	$224,427
2015	2015	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	6	3/25/2015	COMPETING CONTINUATION	$922,140
														Subtotal = $1,146,567

Issue Date FY: 2014 ( Subtotal = $574,676 )
2014	2014	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	5	2/17/2014	NON-COMPETING CONTINUATION	$574,676
														Subtotal = $574,676

Issue Date FY: 2013 ( Subtotal = $796,766 )
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	4	2/12/2013	NON-COMPETING CONTINUATION	$746,966
2013	2013	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	001	4	5/15/2013	NON-COMPETING CONTINUATION	$49,800
														Subtotal = $796,766

Issue Date FY: 2012 ( Subtotal = $766,258 )
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	001	3	6/25/2012	SUPPLEMENT FOR EXPANSION	$29,681
2012	2012	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	3	3/2/2012	NON-COMPETING CONTINUATION	$736,577
														Subtotal = $766,258

Issue Date FY: 2011 ( Subtotal = $653,672 )
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	2	2/9/2011	NON-COMPETING CONTINUATION	$612,074
2011	2011	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	001	2	7/7/2011	NON-COMPETING CONTINUATION	$41,598
														Subtotal = $653,672

Issue Date FY: 2010 ( Subtotal = $653,212 )
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	001	1	4/21/2010	NEW	-$21,869
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	002	1	5/13/2010	NEW	$0
2010	2010	WASHINGTON UNIVERSITY	CAMPUS BOX 1034	SAINT LOUIS	MO	63112	SAINT LOUIS CITY	USA	Mental Health Research Grants	000	1	4/16/2010	NEW	$675,081
														Subtotal = $653,212

Grand Total All Awards = $10,265,897

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Developmental Pathways to Borderline Personality Disorder: Longitudinal Observational, Clinical, and Neural Predictors From Early Childhood to Young Adulthood

Award Number: R01MH090786

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2010

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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