Friday, April 19, 2024 4/19/2024

Contextual Fear Differentiation, Sex Differences and Acetylcholine

Award Number: R01MH062122
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

Fear in nonthreatening contexts is a hallmark of anxiety disorders. The hippocampus' plays a critical role in recognizing a context as a previously experienced dangerous one or a safe one. We will study the ability to differentiate such contexts in rats. Rats have proven to be an excellent model of human anxiety disorders. Rats need a period to explore a context in order to learn that it is dangerous. Our data indicate that a period just long enough to support robust fear learning results in generalizing that fear to any similar context. They need a longer period to learn a specific fear that allows them to distinguish between danger and safety. We will study the biology of this type of learning. We will examine how a particular neuromodulator, acetylcholine (ACh), influences the ability for this learning and have discovered that stimulating this neuromodulatory system enhances the learning. Anxiety disorders are much more prevalent in women and we will test the hypothesis that at certain times during the female cycle, when metabolites of progesterone are high, they act to dampen the brain's response to this neuromodulator. This results in a state where fear learning will be more nonspecific and generalize to safe situations. To study this we will use optogenetics to selectively stimulate ACh and measure release of this neuromodulator with a novel biosensor implanted in a brain region responsible for learning. We will also measure the rhythms of brain activity produced by the neuromodulator, the ability to learn fear and to differentiate safe and dangerous environments. We will compare male and female rats and also compare females in different stages of their cycle. This will provide a deeper understanding of why anxiety disorders develop and why they are more prevalent in women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$99 )
2023	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	19	6/29/2023	NON-COMPETING CONTINUATION	-$99
														Subtotal = -$99

Issue Date FY: 2021 ( Subtotal = $368,325 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	19	1/28/2021	NON-COMPETING CONTINUATION	$368,325
														Subtotal = $368,325

Issue Date FY: 2020 ( Subtotal = $368,325 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	18	1/17/2020	NON-COMPETING CONTINUATION	$368,325
														Subtotal = $368,325

Issue Date FY: 2019 ( Subtotal = $368,325 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	17	1/17/2019	NON-COMPETING CONTINUATION	$368,325
														Subtotal = $368,325

Issue Date FY: 2018 ( Subtotal = $368,325 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	16	1/30/2018	NON-COMPETING CONTINUATION	$331,492
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	16	7/26/2018	NON-COMPETING CONTINUATION	$36,833
														Subtotal = $368,325

Issue Date FY: 2017 ( Subtotal = $360,933 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	15	4/13/2017	COMPETING CONTINUATION	$368,325
2017	2015	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	14	11/10/2016	SUPPLEMENT FOR EXPANSION	-$7,392
														Subtotal = $360,933

Issue Date FY: 2015 ( Subtotal = $620,817 )
2015	2015	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	14	3/18/2015	NON-COMPETING CONTINUATION	$542,004
2015	2015	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	14	8/5/2015	SUPPLEMENT FOR EXPANSION	$78,813
														Subtotal = $620,817

Issue Date FY: 2014 ( Subtotal = $542,064 )
2014	2014	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	13	5/2/2014	NON-COMPETING CONTINUATION	$542,064
														Subtotal = $542,064

Issue Date FY: 2013 ( Subtotal = $520,443 )
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	12	4/4/2013	NON-COMPETING CONTINUATION	$487,914
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	12	5/21/2013	NON-COMPETING CONTINUATION	$32,529
														Subtotal = $520,443

Issue Date FY: 2012 ( Subtotal = $542,188 )
2012	2012	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	11	3/15/2012	NON-COMPETING CONTINUATION	$542,188
														Subtotal = $542,188

Issue Date FY: 2011 ( Subtotal = $496,161 )
2011	2011	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	10	5/16/2011	COMPETING CONTINUATION	$496,161
														Subtotal = $496,161

Issue Date FY: 2010 ( Subtotal = $333,772 )
2010	2010	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	9	3/12/2010	NON-COMPETING CONTINUATION	$333,772
														Subtotal = $333,772

Issue Date FY: 2009 ( Subtotal = $333,772 )
2009	2009	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	8	3/24/2009	NON-COMPETING CONTINUATION	$333,772
														Subtotal = $333,772

Issue Date FY: 2008 ( Subtotal = $449,269 )
2008	2008	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	001	7	8/18/2008	SUPPLEMENT FOR EXPANSION	$115,497
2008	2008	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Mental Health Research Grants	000	7	3/18/2008	NON-COMPETING CONTINUATION	$333,772
														Subtotal = $449,269

Issue Date FY: 2007 ( Subtotal = $333,772 )
2007	2007	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	6	3/16/2007	NON-COMPETING CONTINUATION	$333,772
														Subtotal = $333,772

Issue Date FY: 2006 ( Subtotal = $340,766 )
2006	2006	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	5	5/9/2006	COMPETING CONTINUATION	$340,766
														Subtotal = $340,766

Issue Date FY: 2004 ( Subtotal = $228,750 )
2004	2004	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	4	8/24/2004	NON-COMPETING CONTINUATION	$228,750
														Subtotal = $228,750

Issue Date FY: 2003 ( Subtotal = $228,750 )
2003	2003	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	3	8/25/2003	NON-COMPETING CONTINUATION	$228,750
														Subtotal = $228,750

Issue Date FY: 2002 ( Subtotal = $226,440 )
2002	2002	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	2	8/28/2002	NON-COMPETING CONTINUATION	$226,440
														Subtotal = $226,440

Issue Date FY: 2001 ( Subtotal = $223,039 )
2001	2001	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	10920 WILSHIRE BLVD, 5TH FLOOR	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	1	9/16/2001	NEW	$223,039
														Subtotal = $223,039

Grand Total All Awards = $7,254,137

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Contextual Fear Differentiation, Sex Differences and Acetylcholine

Award Number: R01MH062122

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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