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Improving Peripheral Artery Disease Care Through Community Screening and Virtual Disease Management

Award Number: R01MD020675
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/18/2026
PERIOD OF PERFORMANCE END DATE: 01/31/2031

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Improving Peripheral Artery Disease Care Through Community Screening and Virtual Disease Management - Peripheral artery disease (PAD), the partial or complete occlusion at least one major lower extremity artery by atherosclerotic vascular disease, is a common and highly morbid condition. Widely available and inexpensive medications and lifestyle therapies—including smoking cessation, physical activity, aspirin, and lipid-lowering therapy—can slow the progression of PAD and improve outcomes, but many patients with PAD do not know they have it and remain untreated. PAD outcomes are particularly bad for individuals living in communities with low socioeconomic status (SES), who are less likely to receive subspecialty PAD care and more likely to undergo amputation. Multiple groups have conducted PAD screening events in communities with low SES, but few patients newly identified with PAD at these screening events initiate PAD-specific care. Well-designed virtual disease management platforms have been developed for a number of chronic disease states, and have improved patients’ outcomes. For patients newly diagnosed with PAD, a comprehensive virtual disease management platform should focus on PAD-specific education, encouraging doctor-patient discussions regarding pharmacologic PAD management, promoting physical activity, and connecting patients who smoke with resources for cessation. Our group has tested the effectiveness of virtual disease management platforms incorporating insights from behavioral economics using our NIH-funded Way to Health software platform, which captures patient-generated data and automates the processing of incentives and feedback. In a randomized controlled trial enrolling patients with PAD, an intervention incorporating gamification and education increased physical activity and quality of life compared with control. In this study, we propose a randomized controlled trial, with a 2×2 factorial design, testing two separate components of a PAD virtual disease management platform, based on our successful gamification and education intervention. Partnering with faith-based organizations in Philadelphia, we will conduct screening events for PAD in communities with low SES, high proportions of Black residents, and high amputation rates, and will offer individuals who screen positive the opportunity to enroll in a randomized clinical trial of gamification versus control and a text message-based PAD patient activation program versus usual care. We will address the following aims: Aim 1: To determine whether a text message-based PAD patient activation program is superior to usual care for improving medical management of PAD among people newly diagnosed with PAD and living in high amputation rate, low SES neighborhoods with large proportions of Black residents. Aim 2: To determine whether gamification with automated coaching is superior to usual care for improving physical activity among people newly diagnosed with PAD and living in high amputation rate, low SES neighborhoods with large proportions of Black residents.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $755,882 )
2026	2026	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Minority Health and Health Disparities Research	000	1	8/20/2026	NEW	$755,882
														Subtotal = $755,882

Grand Total All Awards = $755,882

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Improving Peripheral Artery Disease Care Through Community Screening and Virtual Disease Management

Award Number: R01MD020675

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/18/2026

PERIOD OF PERFORMANCE END DATE: 01/31/2031

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