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Advancing communication strategies to support future HIV vaccine use among African Americans in the South.

Award Number: R01MD019024
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/17/2023
PERIOD OF PERFORMANCE END DATE: 04/01/2025

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Advancing communication strategies to support future HIV vaccine use among African Americans in the South. - Abstract As we enter the fifth decade of the HIV pandemic, innovations in HIV vaccine research and development have moved us closer than ever to the availability of effective vaccines that could end HIV acquisition. Unfortunately, vaccine hesitancy (i.e., delay in acceptance or refusal of vaccination despite availability of vaccination services) poses a major threat to the future uptake of a proven vaccine. Globally, people of African descent have been disproportionately burdened by the HIV pandemic, facing higher morbidity and mortality. In the United States, the convergence of racism, mistrust in the healthcaresystem, inadequate community engagement,and concerns regarding vaccine literacy may exacerbate vaccine hesitancy, reducing future uptake within this population. To prepare for an inevitable HIV vaccine, including those with partial efficacy, we need to field-test targeted messaging campaigns that: are persuasive, counter vaccine-related myths and misinformation, come from trusted sources, and are culturally relevant and impactful. Moreover, campaigns must leverage digital platforms to which greater proportions of the population turn for critical health information. Guided by the Capability Opportunity Motivation—Behavior and Minority Health and Health Disparities Research Frameworks, this study will leverage participatory research methods, artificial intelligence, and infrastructure from ongoing HIV vaccine research at Duke University to: 1) Identify preferences regarding HIV vaccine attributes and communication strategies for African Americans in North Carolina using discrete choice experiments; 2) Develop and pilot crowdsourced and deep learning interventions to assess acceptability, feasibility, and preliminary impact on HIV vaccine literacy, confidence, and willingness; and 3) Evaluate the impact of a crowdsourced vs. a deep learning computer animation intervention on HIV vaccine literacy, confidence, and willingness to vaccinate compared to a control arm using a three-arm randomized experiment. The results of this study will: a) enable us to compare outcomes associated with community-driven, community-engaged, and expert-driven interventions to promote favorable attitudes towards an HIV vaccine; b) identify effective HIV vaccine promotion messages for African Americans; c) inform guidelines informing the rollout and promotion of future novel vaccines.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$1,101,467 )
2026	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	000	2	12/5/2025	TERMINATION	-$1,101,467
														Subtotal = -$1,101,467

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	002	2	1/20/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	001	2	12/11/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$795,497
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	003	2	3/7/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	004	2	4/1/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Minority Health and Health Disparities Research	000	1	12/11/2024	NEW	-$795,497
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $766,932 )
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	003	2	6/12/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$23,008
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	001	2	4/17/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$690,239
2024	2024	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Minority Health and Health Disparities Research	002	2	6/5/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$53,685
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Minority Health and Health Disparities Research	000	1	4/17/2024	NEW	$0
														Subtotal = $766,932

Issue Date FY: 2023 ( Subtotal = $795,497 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Minority Health and Health Disparities Research	000	1	8/17/2023	NEW	$795,497
														Subtotal = $795,497

Grand Total All Awards = $460,962

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Advancing communication strategies to support future HIV vaccine use among African Americans in the South.

Award Number: R01MD019024

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/17/2023

PERIOD OF PERFORMANCE END DATE: 04/01/2025

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