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Sexual orientation-related disparities in obstetrical and perinatal health

Award Number: R01MD015256
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/16/2021
PERIOD OF PERFORMANCE END DATE: 03/21/2025

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Sexual orientation-related disparities in obstetrical and perinatal health - PROJECT SUMMARY/ABSTRACT Compared to heterosexual women, sexual minority women (i.e., those with same-sex attractions, same-sex behavior, and/or a lesbian/gay/bisexual identity) are vulnerable to poor gynecological health; for ex- ample, they are more likely to experience sexual assault and to encounter barriers to care. Yet, despite the mounting evidence of these gynecological disparities, little is known about the extent to which obstetrical and perinatal health differ across sexual orientation groups. This gap is especially troubling since sexual minorities have more risk factors (e.g., depression, substance use, obesity) for adverse obstetrical and perinatal out- comes compared to heterosexuals. Few data are available to adequately quantify sexual orientation-related obstetrical and perinatal health disparities, but preliminary results from small, cross-sectional datasets reveal striking disparities: sexual minority women experience twice the number of pregnancies ending in miscarriage and stillbirth and twice the number of children born extremely preterm and low birthweight compared to hetero- sexual women. Quantifying such disparities necessitates the use of large, longitudinal datasets to better inform interventions. This project's objective is to address the knowledge gaps in sexual orientation-related obstetrical and perinatal health by collecting and analyzing national data from three unique, longitudinal, intergenerational cohorts. The Nurses' Health Study 2 (NHS2) began in 1989 when our research group enrolled female nurses aged 25–42 years (now 56–73 years). In 1996 and 2004, our research group enrolled NHS2 offspring aged 9– 16 years (now 25–39 years) into the Growing Up Today Study (GUTS). These cohorts comprise almost 150,000 participants with nearly as many pregnancies, including >30,000 pregnancies among sexual minori- ties. The proposed project will leverage existing data—including nuanced sexual orientation data—to identify new pregnancies among GUTS participants during the height of their reproductive years and collect data about a third generation: the offspring of GUTS participants. Combining these new and existing data will enable us to fill critical gaps, for example by detailing outcomes across different generations and sexual orientation sub- groups (e.g., bisexuals, lesbians). This study will quantify the obstetrical health of sexual minority and hetero- sexual women as well as the perinatal health of children born to sexual minority and heterosexual women. Drawing on the Minority Stress Model, the study will also identify mediators and moderators of sexual orienta- tion-related differences in obstetrical and perinatal health. By collecting detailed, longitudinal data across three generations with data on obstetrical/perinatal outcomes as well as mediators and moderators, the proposed research is a substantive, innovative departure from the status quo. This project will produce the first thorough evaluation of obstetrical and perinatal health of a neglected population—sexual minority women and their off- spring—and will have a positive impact by revealing the needs of these vulnerable groups, informing targeted interventions and improving the health of subsequent generations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	002	5	3/22/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2024	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	000	5	2/18/2025	NON-COMPETING CONTINUATION	$0
2025	2024	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	003	5	3/23/2025	NON-COMPETING CONTINUATION	$0
2025	2024	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	001	5	2/18/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $902,426 )
2024	2024	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	001	5	5/29/2024	NON-COMPETING CONTINUATION	$80,242
2024	2024	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	002	5	9/3/2024	SUPPLEMENT FOR EXPANSION	$99,998
2024	2024	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	000	5	2/2/2024	NON-COMPETING CONTINUATION	$722,186
														Subtotal = $902,426

Issue Date FY: 2023 ( Subtotal = $964,652 )
2023	2023	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	001	4	8/9/2023	SUPPLEMENT FOR EXPANSION	$166,000
2023	2023	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	000	4	2/25/2023	NON-COMPETING CONTINUATION	$798,652
														Subtotal = $964,652

Issue Date FY: 2022 ( Subtotal = $1,171,038 )
2022	2022	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Minority Health and Health Disparities Research	002	3	2/17/2022	NON-COMPETING CONTINUATION	$675,449
2022	2022	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Minority Health and Health Disparities Research	003	3	5/3/2022	NON-COMPETING CONTINUATION	$80,589
2022	2022	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Minority Health and Health Disparities Research	004	3	7/15/2022	SUPPLEMENT FOR EXPANSION	$415,000
2022	2021	HARVARD PILGRIM HEALTH CARE INC	1 WELLNESS WAY	CANTON	MA	02021	NORFOLK	USA	Minority Health and Health Disparities Research	001	2	1/11/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$49,831
2022	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Minority Health and Health Disparities Research	000	1	1/11/2022	NEW	-$49,831
														Subtotal = $1,171,038

Issue Date FY: 2021 ( Subtotal = $929,389 )
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Minority Health and Health Disparities Research	001	1	9/27/2021	NEW	-$879,558
2021	2021	HARVARD PILGRIM HEALTH CARE INC	93 WORCESTER ST	WELLESLEY	MA	02481	NORFOLK	USA	Minority Health and Health Disparities Research	002	2	9/27/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$879,558
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Minority Health and Health Disparities Research	000	1	5/16/2021	NEW	$929,389
														Subtotal = $929,389

Grand Total All Awards = $3,967,505

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Sexual orientation-related disparities in obstetrical and perinatal health

Award Number: R01MD015256

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/16/2021

PERIOD OF PERFORMANCE END DATE: 03/21/2025

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