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Transfer Learning for Digital Curation of the EMR Clinical Narrative

Award Number: R01LM013486
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/12/2021
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Transfer Learning for Digital Curation of the EMR Clinical Narrative - Project Summary This proposal is in response to PAR 18-796 to seek support for advancing methodologies for a transfer learning framework for the digital curation of the Electronic Medical Records (EMR) clinical narrative. In the current era of increasing importance of Artificial Intelligence (AI) in biomedicine, our proposal tackles a critical AI component – automated annotation of health-related text. Since 2015 the development and application of machine learning (ML) methods has exploded propelled by the convergence of plentiful digitized unstructured data (text, speech, images), hardware and the refinement of neural networks or deep learning. 2018 marked a turning point in Natural Language Processing (NLP), particularly transfer learning through pre-trained models like Universal Language Model Fine-tuning for Text Classification, Allen AI's ELMO, OpenAI's Open-GPT. In November 2018, Google published the Bidirectional Encodings Representations from Transformers (BERT), a transformer-based model pre-trained on massive general text databases (3.3B words total). The publication reported using BERT representations to build classifiers for 11 NLP tasks which outperformed the state-of-the- art (SOTA) with large margins. The NLP research community jumped to the idea of exploring this new framework but quickly came to the realization that building BERT-style models from scratch is affordable and feasible to only a few. Thus, research investigation proceeded in the direction of using these gigantic models as resources for language representations. Scientific efforts focused on pre-trained models (e.g. BERT) as a source of extracting high quality language features or fine-tuning on a specific task, i.e. using a model as a checkpoint and re-training with much smaller amounts of task-specific data to produce predictions by typically adding one fully-connected layer on top of the representations and training for a few epochs. This general watershed shift in NLP to transfer learning which parallels the developments in computer vision a few years ago coupled with our latest work brings to the forefront a critical NLP research topic ripe for exploration – a transfer learning framework for the digital curation of the EMR clinical narrative. The proposed work is research of novel scientific methods for extracting detailed information from health-related text especially the EMR, the major source of phenotype data for patients. Precise phenotype information is needed to advance translational research, particularly to unravel the effects of genetic, epigenetic, and systems changes on responsiveness. This research is in line with the latest developments in neural deep learning approaches and AI in general and is expected to enhance biomedical research and through that the health of the public.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Medical Library Assistance	000	4	12/24/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Medical Library Assistance	000	4	3/3/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $376,125 )
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Medical Library Assistance	000	4	5/22/2024	NON-COMPETING CONTINUATION	$376,125
														Subtotal = $376,125

Issue Date FY: 2023 ( Subtotal = $376,125 )
2023	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Medical Library Assistance	000	3	6/16/2023	NON-COMPETING CONTINUATION	$376,125
														Subtotal = $376,125

Issue Date FY: 2022 ( Subtotal = $376,125 )
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Medical Library Assistance	000	2	6/16/2022	NON-COMPETING CONTINUATION	$376,125
														Subtotal = $376,125

Issue Date FY: 2021 ( Subtotal = $376,125 )
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Medical Library Assistance	000	1	8/12/2021	NEW	$376,125
														Subtotal = $376,125

Grand Total All Awards = $1,504,500

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Transfer Learning for Digital Curation of the EMR Clinical Narrative

Award Number: R01LM013486

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/12/2021

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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