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Distance-based Panomic Analytics for Microbiome Data

Award Number: R01LM012517
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Distance-based Panomic Analytics for Microbiome Data - PROJECT SUMMARY Our ability to study the microbiomes is enabled by the same technologies that allow us to quantify the host physiological state at greater depth and precision, including advanced high-throughput sequencing for genomics and transcriptomics; mass spectrometry for metabolomics, proteomics, and lipidomics; and flow-cytometry for characterization of circulating cell populations. The integration of host and microbiome panomic data is the roadmap for future biomedical discoveries. One example of such studies is the Integrative Human Microbiome Project (iHMP), which is currently generating panomic data on microbes and their host environment in three different diseases (diabetes, irritable bowel disease, pre-term delivery). Lack of appropriate analytics for these data and a steep curve for their validation and adoption is a major concern for the community. The main challenge of inference in panomic-scale microbiome datasets is overcoming the ‘curses of dimensionality’. Local causal learning has proven useful for making discoveries with high-dimensional data, while distance-based learning is a promising paradigm for multivariate data analysis. We are proposing to combine these to develop the next generation of panomic data analytics and make these tools available directly to the biomedical investigators. The aims of this project are: (1) Develop analytics for distance-based omnibus panomic integration; (2) Develop methodology for top-down distance-based sub-system interdependence learning. The overarching goal is to develop user-facing applications utilizing the methodologies in Aims 1 and 2 and apply those in several existing studies generating panomic data. The analytics, applications, and educational resources (case studies and tutorials) resulting from this project will enable the biomedical community to study panomic-scale datasets in a coherent and comprehensive way. The methods and tools resulting from this project will support new biomedical discoveries. ! !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$13,803 )
2024	2021	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Medical Library Assistance	000	4	11/14/2023	NON-COMPETING CONTINUATION	-$13,803
														Subtotal = -$13,803

Issue Date FY: 2021 ( Subtotal = $321,864 )
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Medical Library Assistance	001	4	4/30/2021	NON-COMPETING CONTINUATION	$16,095
2021	2021	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Medical Library Assistance	000	4	4/13/2021	NON-COMPETING CONTINUATION	$305,769
														Subtotal = $321,864

Issue Date FY: 2020 ( Subtotal = $327,071 )
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Medical Library Assistance	000	3	4/3/2020	NON-COMPETING CONTINUATION	$310,716
2020	2020	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Medical Library Assistance	001	3	5/15/2020	NON-COMPETING CONTINUATION	$16,355
														Subtotal = $327,071

Issue Date FY: 2019 ( Subtotal = $337,824 )
2019	2019	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Medical Library Assistance	000	2	3/29/2019	NON-COMPETING CONTINUATION	$337,824
														Subtotal = $337,824

Issue Date FY: 2018 ( Subtotal = $337,824 )
2018	2018	MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Medical Library Assistance	000	1	5/31/2018	NEW	$337,824
														Subtotal = $337,824

Grand Total All Awards = $1,310,780

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Distance-based Panomic Analytics for Microbiome Data

Award Number: R01LM012517

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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