Thursday, November 21, 2024 11/21/2024

Social Media Mining for Pharmacovigilance

Award Number: R01LM011176
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Drugs undergo extensive testing in animals and clinical trials in humans before they are marketed for widespread use. Pre-market testing produces reasonably high quality information about the efficacy of the drug as a treatment for the condition for which it was approved, but gives a very incomplete picture of the drug's safety. It is only after a drug is marketed and used on a more widespread basis over longer periods of time that it is possible to identify other effects, such as rare but serious adverse effects, or those that are more common in the special subgroups excluded from the trial (such as pregnant women), or effects of long-term use of the drug, among others. Despite the increase in research in the past years exploring social media data for pharmacovigilance, and the evidence that it indeed can bring forward the patient perspective, there is no systematic approach to collect and annotate such data for research purposes. This renewal builds on our prior research and natural language processing (NLP) methods for social media mining in pharmacovigilance to make the collection of social media data about medication use precise and systematic enough to be useful to researchers and the public, alongside established sources such as the FDA's data and other public collections of drug adverse event data. It presents innovative methods to automatically collect and analyze longitudinal health data, piloting methods for interventions through the same media that can inform the public and help validate the automatic methods. As validation, we include a comparison to an existing reference standard for adverse effects that integrates FDA's data and HER data, as well as specific case studies focused on (Aim 3.1) the use of NSAIDs and anti-depressants in pregnancy and (Aim 3.2) factors for non-adherence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	9	10/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = -$53,589 )
2024	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	9	8/29/2024	SUPPLEMENT FOR EXPANSION	-$6,459
2024	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	9	8/29/2024	NON-COMPETING CONTINUATION	-$28,000
2024	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	002	9	8/29/2024	SUPPLEMENT FOR EXPANSION	-$19,130
														Subtotal = -$53,589

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	9	7/31/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	9	7/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	9	5/23/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	002	9	5/23/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	9	5/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,137,142 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	002	9	6/11/2021	SUPPLEMENT FOR EXPANSION	$137,053
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	9	6/10/2021	NON-COMPETING CONTINUATION	$594,153
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	8	4/5/2021	SUPPLEMENT FOR EXPANSION	$67,501
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	003	9	6/14/2021	SUPPLEMENT FOR EXPANSION	$338,435
														Subtotal = $1,137,142

Issue Date FY: 2020 ( Subtotal = $723,327 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	8	7/21/2020	SUPPLEMENT FOR EXPANSION	$113,012
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	8	5/29/2020	NON-COMPETING CONTINUATION	$610,315
														Subtotal = $723,327

Issue Date FY: 2019 ( Subtotal = $630,708 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	7	5/21/2019	NON-COMPETING CONTINUATION	$630,471
2019	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	6	5/16/2019	COMPETING CONTINUATION	$237
														Subtotal = $630,708

Issue Date FY: 2018 ( Subtotal = $660,005 )
2018	2018	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	6	9/13/2018	COMPETING CONTINUATION	$660,242
2018	2015	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	000	5	6/27/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$237
														Subtotal = $660,005

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2015	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	003	5	2/23/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$696
2017	2015	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Medical Library Assistance	000	4	2/9/2017	NON-COMPETING CONTINUATION	-$55,998
2017	2015	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Medical Library Assistance	002	4	2/23/2017	NON-COMPETING CONTINUATION	-$696
2017	2015	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	001	5	2/9/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$55,998
2017	2015	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Medical Library Assistance	004	5	9/22/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $338,807 )
2015	2015	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Medical Library Assistance	000	4	8/8/2015	NON-COMPETING CONTINUATION	$338,807
														Subtotal = $338,807

Issue Date FY: 2014 ( Subtotal = $338,807 )
2014	2014	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Medical Library Assistance	000	3	8/16/2014	NON-COMPETING CONTINUATION	$338,807
														Subtotal = $338,807

Issue Date FY: 2013 ( Subtotal = $320,208 )
2013	2013	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Medical Library Assistance	000	2	8/15/2013	NON-COMPETING CONTINUATION	$320,208
														Subtotal = $320,208

Issue Date FY: 2012 ( Subtotal = $361,875 )
2012	2012	ARIZONA STATE UNIVERSITY	P.O. BOX 873503	TEMPE	AZ	85287	MARICOPA	USA	Medical Library Assistance	000	1	9/7/2012	NEW	$361,875
														Subtotal = $361,875

Grand Total All Awards = $4,457,290

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Social Media Mining for Pharmacovigilance

Award Number: R01LM011176

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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