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Hidden Layers of RNA Regulation in Inflammation, Lipid Metabolism, and Atherosclerosis

Award Number: R01HL185164
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Hidden Layers of RNA Regulation in Inflammation, Lipid Metabolism, and Atherosclerosis - PROJECT SUMMARY Gene perturbations contribute to most forms of cardiovascular disease (CVD). Long noncoding RNAs represent the largest class of genes, but their precise role in CVD remains an enigma, representing both a challenge and compelling opportunity for discovery. Our group became involved with lncRNA discovery shortly after the field’s inception. Equipped with a trove of unique resources and expertise, we are excited to pursue this proposal with the overarching objective of enhancing our understanding of how noncoding transcripts contribute to lipid metabolism, inflammation and atherosclerosis. We performed two independent screening strategies to unravel roles for lncRNAs in cardiometabolic diseases. We discovered a completely uncharacterized macrophage micropeptide, BRIK, and a liver-specific lncRNA we named Hindr. Drawing from robust preliminary data, we hypothesize that BRIK integrates metabolic and immune signaling, and we propose studies that will test its role in macrophage function and atherosclerosis (Aim 1). We further surmise that Hindr regulates hepatic lipid metabolism and propose a series of molecular, cellular and animal experiments to extend our preliminary data and test out hypothesis (Aim 2). Our studies will provide foundational insights into how noncoding RNA contribute to atherosclerosis pathways and have the potential to reveal new targets for cardiometabolic disease mitigation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,564,296 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Cardiovascular Diseases Research	000	1	7/7/2026	NEW	$1,564,296
														Subtotal = $1,564,296

Grand Total All Awards = $1,564,296

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Hidden Layers of RNA Regulation in Inflammation, Lipid Metabolism, and Atherosclerosis

Award Number: R01HL185164

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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