Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

The PE-TRACT EXTEND study: chronic thromboembolism following intermediate-risk PE

Award Number: R01HL183994
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2030

Group Awards By:

View Award Description

The PE-TRACT EXTEND study: chronic thromboembolism following intermediate-risk PE - PROJECT SUMMARY This prospective cohort study, PE-TRACT-EXTEND, uses the study population from the NHLBI-funded randomized trial of catheter-directed therapy (CDT) for acute PE (PE-TRACT, 5UH3HL155798) to address two important aspects of post-PE disability not evaluated in the parent study: 1) the prevalence of symptomatic, exercise-limiting, residual pulmonary vascular obstruction, which we call “chronic thromboembolism,” after PE treatment and its associated morbidity and mortality beyond PE-TRACT's 1-year follow up; and 2) the influence of specific biological/molecular processes on the etiology of chronic thromboembolism. The project will determine the frequency and distribution of chronic thromboembolism phenotypes among PE- TRACT participants after the 1-year parent study period with a validated algorithm involving step-wise application of cardiopulmonary exercise testing, ventilation-perfusion scanning, echocardiography, anatomic imaging, and right heart catheterization. It will evaluate the clinical importance of chronic thromboembolism phenotypes through their association with survival and validated measurements of functional limitations. It will also explore whether CDT modifies the risk of subsequent chronic thromboembolism by comparing the occurrences of chronic thromboembolism phenotypes between the PE-TRACT CDT and No-CDT groups. The project will also provide biological insights about etiologic mechanisms of chronic thromboembolism through a genomic and proteomic analysis of post-PE patients independently phenotyped as either “chronic thromboembolism” or “not chronic thromboembolism.” The investigators will genotype DNA variants in the fibrinogen and HLA loci, extract fibrinogen for fibrinolysis assays, and measure inflammatory markers using existing biorepository blood samples from the PE-TRACT cohort. It will determine the interplay between biological processes, embolic burden, and clinical variables on chronic thromboembolism through a multivariate analysis with the goal of identifying potential biomarkers of chronic thromboembolism and molecular targets to advance its diagnosis, prevention and treatment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $936,356 )
2026	2026	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Blood Diseases and Resources Research	000	1	8/13/2026	NEW	$936,356
														Subtotal = $936,356

Grand Total All Awards = $936,356

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The PE-TRACT EXTEND study: chronic thromboembolism following intermediate-risk PE

Award Number: R01HL183994

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer