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GP130 Antagonism in Porcine RV Pressure Overload

Award Number: R01HL162927
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/27/2025
PERIOD OF PERFORMANCE END DATE: 10/31/2026

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GP130 Antagonism in Porcine RV Pressure Overload - Project Summary Pulmonary arterial hypertension (PAH) is a lethal disease with a median survival of only 5-7 years. Pathophysiologically, PAH is a progressive vasculopathy of the precapillary pulmonary vessels that increases pulmonary arterial pressures and pulmonary vascular resistance while reducing pulmonary arterial compliance. The changes in the pulmonary vasculature augment the work load of the right ventricle, which ultimately results in right ventricular dysfunction (RVD). The presence of RVD is the greatest risk factor for death in PAH; however, no current PAH therapies actually target the RV directly. In this proposal, we will investigate the hypothesis that GP130 activation in RV cardiomyocytes promotes cardiomyocyte dysfunction via microtubule remodeling which causes t-tubule derangements and mitochondrial metabolic dysfunction. We will use state- of-the-art approaches to probe the molecular and physiological effects of GP130 antagonism on right ventricular function in porcine RV failure.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2026	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Lung Diseases Research	002	5	5/7/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$665,947
2026	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	001	4	4/27/2026	NON-COMPETING CONTINUATION	$9,408
2026	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	000	4	4/22/2026	NON-COMPETING CONTINUATION	-$675,355
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $675,355 )
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	000	4	4/15/2025	NON-COMPETING CONTINUATION	$607,820
2025	2025	REGENTS OF THE UNIVERSITY OF MINNESOTA	2221 UNIVERSITY AVE SE STE 100	MINNEAPOLIS	MN	55414	HENNEPIN	USA	Lung Diseases Research	001	4	6/26/2025	NON-COMPETING CONTINUATION	$67,535
														Subtotal = $675,355

Issue Date FY: 2024 ( Subtotal = $1,301,611 )
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Cardiovascular Diseases Research	001	3	8/29/2024	SUPPLEMENT FOR EXPANSION	$639,763
2024	2024	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Lung Diseases Research	000	3	5/8/2024	NON-COMPETING CONTINUATION	$661,848
														Subtotal = $1,301,611

Issue Date FY: 2023 ( Subtotal = $675,355 )
2023	2023	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Lung Diseases Research	000	2	6/9/2023	NON-COMPETING CONTINUATION	$675,355
														Subtotal = $675,355

Issue Date FY: 2022 ( Subtotal = $675,355 )
2022	2022	REGENTS OF THE UNIVERSITY OF MINNESOTA	200 OAK ST SE # 224	MINNEAPOLIS	MN	55455	HENNEPIN	USA	Lung Diseases Research	000	1	5/1/2022	NEW	$675,355
														Subtotal = $675,355

Grand Total All Awards = $3,327,676

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GP130 Antagonism in Porcine RV Pressure Overload

Award Number: R01HL162927

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/27/2025

PERIOD OF PERFORMANCE END DATE: 10/31/2026

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