Tuesday, August 12, 2025 8/12/2025

Precision Approaches to Reduce Asthma Disparities with Electronic Health Record Data

Award Number: R01HL162354
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2026

Group Awards By:

View Award Description

Precision Approaches to Reduce Asthma Disparities with Electronic Health Record Data - Asthma, a chronic disease that manifests as airway hyperresponsiveness to specific environmental stimuli, affects over 20 million American adults. Disparities in adult asthma prevalence, severity, and death in the U.S. are well known but few approaches have significantly decreased them. Studies of real-world populations such as those derived from Electronic Health Records (EHRs) are invaluable to guide the design of personalized care strategies because they capture a large number of diverse and vulnerable people. Additionally, EHR data can be leveraged to identify geospatial areas where people are at peak risk of a condition by studying the geographic distribution of affected patients. We have identified individual- and area-level factors that are associated with asthma using EHRs linked to rich and diverse sources of social, economic, and environmental variables, and we have developed methods to appropriately extract information from EHR data that are heterogeneously available across patients and reduce bias in the analysis of these imperfect data. This proposal will identify sub-groups of adults with asthma who share common patterns of demographic, clinical, social, and environmental exposure characteristics using EHR data augmented with data on social, economic, and environmental factors, which will enable the design of effective precision strategies to reduce asthma exacerbations. Our aims are to: 1) develop and validate natural language processing (NLP) algorithms to extract social, occupational and allergy information from EHR notes; 2) determine geospatial areas that have increased asthma exacerbation risk using spatial generalized linear mixed models and identify risk factors in these areas; and 3) use Bayesian hierarchical clustering techniques to identify asthma sub-phenotypes that will form the basis of a clinical decision support tool that offers precision care strategies. This project will result in the creation of a tool that can assist in the care of adults with asthma based on actionable risk factors and motivate public health strategies to mitigate the burden of asthma in specific regions. Our novel data integration approaches, sub-phenotyping methods, and software developed will have broad applicability for the study of any condition using EHR or other real-world data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $767,057 )
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	001	4	7/24/2025	NON-COMPETING CONTINUATION	$767,057
2025	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	3	12/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $767,057

Issue Date FY: 2024 ( Subtotal = $766,477 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	3	8/20/2024	NON-COMPETING CONTINUATION	$766,477
														Subtotal = $766,477

Issue Date FY: 2023 ( Subtotal = $796,746 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	2	8/8/2023	NON-COMPETING CONTINUATION	$796,746
														Subtotal = $796,746

Issue Date FY: 2022 ( Subtotal = $812,274 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Lung Diseases Research	000	1	8/23/2022	NEW	$812,274
														Subtotal = $812,274

Grand Total All Awards = $3,142,554

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Precision Approaches to Reduce Asthma Disparities with Electronic Health Record Data

Award Number: R01HL162354

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer