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Are Interventions Supporting Physical ACtivity modified by the Environment (InSPACE)?

Award Number: R01HL157166
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Are Interventions Supporting Physical ACtivity modified by the Environment (InSPACE)? - Most youth and adults in the U.S. do not meet recommended levels of physical activity, despite the significant and extensive health benefits associated with being sufficiently active. Interventions to increase physical activity are critical to improving an individuals' and population health. However, generally efficacious interventions may not be consistently effective across individuals. Personalized behavioral medicine in which interventions are tailored to the context in which individuals are attempting to improve health behaviors remains a nascent field. Among context factors, built and social environment factors within the home neighborhood are related cross-sectionally to individuals' physical activity (e.g., residents in more walkable neighborhoods are generally more active). However, cross-sectional observational studies do not identify whether or which environmental factors are facilitators or barriers to attempts to increase physical activity. The proposed InSPACE project examines whether and which home neighborhood built and social environment factors affect individuals' response to physical activity interventions. We propose to recruit and engage with 50+ physical activity intervention trials across the country to generate comprehensive and consistent measures of objective built (e.g., residential density) and social (e.g., median household income) neighborhood environment linked to individual participants within each trial. Advances in the availability of national spatial data and an innovative user-friendly tool to create and attribute environmental measures to anywhere in the U.S. (the Automatic Context Measurement Tool) makes InSPACE timely and feasible. Environmental, physical activity outcome, and demographic data will be harmonized across trials and pooled to allow for robust testing of environmental effect modification of physical activity intervention not possible within single trials. In addition, pooled data will allow for testing of whether critical individual-level demographic factors, such as age and race/ethnicity, interact with neighborhood environmental factors in affecting physical activity intervention outcome. Guided by an expert scientific advisory council, findings from InSPACE have the potential to rapidly and efficiently identify who will be responsive to existing efficacious physical activity interventions in what contexts and encourage innovation in changing interventions to better match individuals' environmental contexts when attempting to increase physical activity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $562,509 )
2024	2024	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	000	4	5/6/2024	NON-COMPETING CONTINUATION	$516,590
2024	2024	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	001	4	6/12/2024	NON-COMPETING CONTINUATION	$45,919
														Subtotal = $562,509

Issue Date FY: 2023 ( Subtotal = $748,196 )
2023	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	000	3	4/27/2023	NON-COMPETING CONTINUATION	$716,023
2023	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	001	3	5/3/2023	SUPPLEMENT FOR EXPANSION	$32,173
														Subtotal = $748,196

Issue Date FY: 2022 ( Subtotal = $929,666 )
2022	2022	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	001	2	8/29/2022	SUPPLEMENT FOR EXPANSION	$69,626
2022	2022	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	000	2	4/19/2022	NON-COMPETING CONTINUATION	$860,040
														Subtotal = $929,666

Issue Date FY: 2021 ( Subtotal = $767,757 )
2021	2021	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	001	1	7/28/2021	NEW	$0
2021	2021	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	002	1	8/18/2021	NEW	$87,133
2021	2021	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Cardiovascular Diseases Research	000	1	4/28/2021	NEW	$680,624
														Subtotal = $767,757

Grand Total All Awards = $3,008,128

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Are Interventions Supporting Physical ACtivity modified by the Environment (InSPACE)?

Award Number: R01HL157166

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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