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Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular Disease

Award Number: R01HL155717
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular Disease - PROJECT SUMMARY Though knowledge advances have been made in identification and treatment of risk factors, cardiovascular disease (CVD) remains the leading cause of death in the U.S., and has been worldwide for the past 15 years. The mechanisms of three leading sources of CVD morbidity, ischemic coronary artery disease, heart failure, and atrial fibrillation, appear rooted in myocardial pathophysiology of the left ventricle (LV), suggesting that deeper phenotyping of the LV may provide insight into the diseases. The detection of earliest forms of LV dysfunction has been challenging: traditional measures of LV structure and function associated with poor outcomes, such as mass and ejection fraction, reflect advanced stages of disease. However, recent advances in quantitative imaging of the LV myocardium using cardiovascular magnetic resonance (CMR) images may bridge this gap. Myocardial texture analysis is a type of ‘radiomics’, the computation of myocardial pixel intensity and patterns, which has shown the ability to differentiate pathological patterns in LV hypertrophy. Additionally, analysis of myocardial mechanics including strain and torsion have shown prognostic value in evaluation of cardiomyopathies. Thus, increasing evidence indicates roles for these technological advances in imaging analysis to evaluate pathological LV remodeling in subclinical cardiovascular disease in the general population. We hypothesize that application of these novel imaging analytics, correlated with biology, subclinical disease phenotyping, and outcomes, will enable more granular insight into subclinical LV structural and functional changes predating overt CVD and its forms. The Framingham and Jackson Heart Studies, community-based cohorts of whites and African Americans with longitudinal follow up, offer the opportunity to gain insight in CVD development through integration of advanced secondary imaging analysis with detailed and broad phenotyping and genotyping, and clinical end-points. Thus, the objectives of our proposal are threefold: 1) to first identify myocardial texture analysis and mechanics patterns associated with prevalent CVD and risk factors, 2) to define the biological and genetic underpinnings of these phenotypes, and 3) to understand their inter-association between structure and function, and their joint relations with long-term prognosis. Execution of our Aims will elucidate novel patterns, determinants, and prognosis of underlying early and progressive myocardial remodeling and dysfunction in CVD in a large bi-racial cohort. Ultimately, our goal is for knowledge gained from this study to advance phenotyping of LV remodeling groups, methods of cardiovascular risk stratification, and development of therapies for patient care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	5	1/13/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $832,373 )
2025	2025	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	5	7/31/2025	NON-COMPETING CONTINUATION	$832,373
														Subtotal = $832,373

Issue Date FY: 2024 ( Subtotal = $823,436 )
2024	2024	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	001	4	6/21/2024	NON-COMPETING CONTINUATION	$67,218
2024	2024	BETH ISRAEL DEACONESS MEDICAL CENTER, INC.	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	4	3/28/2024	NON-COMPETING CONTINUATION	$756,218
														Subtotal = $823,436

Issue Date FY: 2023 ( Subtotal = $844,896 )
2023	2023	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	3	2/27/2023	NON-COMPETING CONTINUATION	$844,896
														Subtotal = $844,896

Issue Date FY: 2022 ( Subtotal = $851,157 )
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	2	2/18/2022	NON-COMPETING CONTINUATION	$766,040
2022	2022	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	001	2	6/18/2022	NON-COMPETING CONTINUATION	$85,117
														Subtotal = $851,157

Issue Date FY: 2021 ( Subtotal = $708,497 )
2021	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	1	3/15/2021	NEW	$639,525
2021	2021	BETH ISRAEL DEACONESS MEDICAL CENTER, INC	330 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	001	1	7/29/2021	NEW	$68,972
														Subtotal = $708,497

Grand Total All Awards = $4,060,359

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Myocardial Radiomics and Mechanics in the Pathology and Prognosis of Cardiovascular Disease

Award Number: R01HL155717

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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