Friday, April 26, 2024 4/26/2024

Volumetric Echocardiographic Particle Image Velocimetry for Grading the Severity of Mitral Valve Regurgitation

Award Number: R01HL153724
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

View Award Abstract

PROJECT SUMMARY/ABSTRACT Optimal management of patients with mitral regurgitation (MR) involves accurate grading for the disease timely intervention, proper follow-up, and patient-specific therapeutic decision-making. A recent study in France showed that although MR was clearly identified and coded in the patients' discharge summary, only less than 10% of those admitted with significant MR underwent a valve intervention within 1 year. This leaves a vast majority of the patients untreated. They found that the rate of mitral valve intervention was significantly low for both primary and secondary MR. This high level of undertreatment is even more striking considering that all individuals were inpatients, admitted to French hospitals with relatively easy access to cardiologists. Alternatively, a significant and unfortunate outcome of inaccurate grading of MR severity is over-treatment of the patients whose grade of valve regurgitation has been erroneously reported. Every so often patients undergo unnecessary corrective procedures due to misgrading their MR. The under- or over-treatment is a significant and unfortunate outcome of inaccurate grading of MR severity. Volumetric Echo-PIV visualizes and quantifies 3D blood flow velocity field from echocardiographic data based on the governing equations of the flow. Given the ubiquitous availability of the echocardiography systems, V- Echo-PIV is inexpensive, accurate, and accessible. Funded by 1 R01 HL153724-01A1, we are currently studying the feasibility of V-Echo-PIV as a tool to assess right ventricular (RV) flow for diagnosis and follow up of patients with pulmonary hypertension (PH). These patients require frequent monitoring, often including repeated invasive right heart catheterization (RHC) due to their clinical status, which has led to a significant healthcare burden. Noninvasively derived RV hemodynamics indices from V-Echo-PIV that correlate with PH patients' clinical condition could significantly reduce the cost and morbidity of the current invasive tests. Based on our recent success in characterizing the RV blood flow in the PH patients and healthy control subjects, this supplement award seeks to study the feasibility of V-Echo-PIV to quantify MR and thus eliminate intra- and inter-operator variability in grading MR. V-Echo-PIV utilizes matrix array ultrasound transducers of current standard echocardiography systems and requires only a few heartbeats (up to 4) to process and obtain the blood flow's 3D velocity vector field in the heart chambers. We hypothesize that by measuring the 3D velocity field in the left ventricle and left atrium via V-Echo-PIV, it is possible to characterize the flow conversion zone in 3D and accurately grade MR. To achieve the proposed research objectives, the following specific aims are set to be accomplished in a 1-year duration of the project: SPECIFIC AIM 1: Devise a protocol for high-speed contrast 3D echocardiography to image the flow in the left heart to characterize and grade mitral valve regurgitation. SPECIFIC AIM 2: Characterize the flow conversion zone in 3D by means of V-Echo-PIV in a prospective cohort of patients with mitral valve regurgitation to accurately grade MR severity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Lung Diseases Research	000	2	3/1/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,290,560 )
2023	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Lung Diseases Research	002	2	9/12/2023	SUPPLEMENT FOR EXPANSION	$645,279
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Lung Diseases Research	001	2	3/15/2023	NON-COMPETING CONTINUATION	$64,529
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Lung Diseases Research	000	2	1/6/2023	NON-COMPETING CONTINUATION	$580,752
														Subtotal = $1,290,560

Issue Date FY: 2022 ( Subtotal = $671,932 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Lung Diseases Research	000	1	1/15/2022	NEW	$671,932
														Subtotal = $671,932

Grand Total All Awards = $1,962,492

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Volumetric Echocardiographic Particle Image Velocimetry for Grading the Severity of Mitral Valve Regurgitation

Award Number: R01HL153724

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer