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Stress and Cardiovascular Risk Among Urban African American Adults: A Multilevel, Mixed Methods Approach:Supplement

Award Number: R01HL153377
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/20/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Stress and Cardiovascular Risk Among Urban African American Adults: A Multilevel, Mixed Methods Approach:Supplement - PROJECT SUMMARY/ABSTRACT The proposed study will utilize two waves of data from the parent study titled Stress and Cardiovascular Risk Among Urban African American Adults: A Multilevel, Mixed Methods Approach (R01 HL153377-01A1), led by Dr. Samuele Zilioli. This parent study aims to identify pathways linking psychosocial stressors to cardiovascular risk among middle-aged and older African Americans. Our study will include 526 asymptomatic African Americans, aged 55-77, residing in metro Detroit. Aligned with the broad overarching goals of the parent study of exploring the relationship between social ecology and cardiovascular risk in midlife and older age, we will investigate the prospective associations between religiosity and inflammation. Our theoretical model proposes that religion can influence cardiovascular disease through three mediating pathways: psychological, social, and behavioral. To date, no study has collectively tested these pathways among middle-aged and older African American adults. Using multiple latent change score modeling, we hypothesize that greater religious attendance will be associated with more positive religious coping, higher perceived social support, and lower alcohol usage, which in turn will be associated with lower inflammation levels (i.e., basal and stimulated cytokines). Understanding these mediating pathways could inform culturally tailored interventions that harness the protective effects of religion as a social determinant of cardiovascular health for African American adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $22,821 )
2025	2025	WAYNE STATE UNIVERSITY	5700 CASS AVE STE 4900	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	002	4	6/6/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2025	WAYNE STATE UNIVERSITY	5700 CASS AVE STE 4900	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	001	4	12/15/2024	SUPPLEMENT FOR EXPANSION	$22,821
2025	2024	WAYNE STATE UNIVERSITY	5700 CASS AVE STE 4900	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	000	4	12/2/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $22,821

Issue Date FY: 2024 ( Subtotal = $627,154 )
2024	2024	WAYNE STATE UNIVERSITY	5700 CASS AVE STE 4900	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	000	4	3/28/2024	NON-COMPETING CONTINUATION	$575,960
2024	2024	WAYNE STATE UNIVERSITY	5700 CASS AVE STE 4900	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	001	4	6/21/2024	NON-COMPETING CONTINUATION	$51,194
														Subtotal = $627,154

Issue Date FY: 2023 ( Subtotal = $657,539 )
2023	2023	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	000	3	4/10/2023	NON-COMPETING CONTINUATION	$657,539
														Subtotal = $657,539

Issue Date FY: 2022 ( Subtotal = $663,339 )
2022	2022	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	000	2	3/17/2022	NON-COMPETING CONTINUATION	$597,003
2022	2022	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	001	2	6/29/2022	NON-COMPETING CONTINUATION	$66,336
														Subtotal = $663,339

Issue Date FY: 2021 ( Subtotal = $705,264 )
2021	2021	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	001	1	8/4/2021	NEW	$0
2021	2021	WAYNE STATE UNIVERSITY	5057 WOODWARD STE 13001	DETROIT	MI	48202	WAYNE	USA	Cardiovascular Diseases Research	000	1	4/16/2021	NEW	$705,264
														Subtotal = $705,264

Grand Total All Awards = $2,676,117

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Stress and Cardiovascular Risk Among Urban African American Adults: A Multilevel, Mixed Methods Approach:Supplement

Award Number: R01HL153377

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/20/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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