Monday, June 23, 2025 6/23/2025

Aspirin to prevent cardiac dysfunction in preeclampsia

Award Number: R01HL148191
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Aspirin to prevent cardiac dysfunction in preeclampsia - ABSTRACT Preeclampsia (PE) is a disease of late pregnancy characterized by hypertension and organ damage, which not only increases peripartum morbidity but is associated with the postpartum development of heart failure, including myocardial fibrosis and systolic heart failure. Despite two decades of research demonstrating this association and a large public health burden, the molecular mechanisms mediating PE-induced postpartum heart failure remain poorly understood and therapies to prevent this outcome are lacking. One potential trigger may be the profibrotic growth factor Activin A, a member of the transforming growth factor beta family produced by the placenta and inflammatory cells. Using a randomized mechanistic clinical trial of aspirin vs. placebo for patients with preeclampsia, integrated with studies of the mechanisms by which aspirin and Activin A might affect the heart, we will dramatically advance knowledge of cardiac dysfunction in preeclampsia and its possible treatments. We pursue two specific aims to answer these questions. AIM 1 is a randomized trial to test whether aspirin improves cardiac function and decreases Activin A in women with preeclampsia. AIM 2 Identifies how increased plasma Activin A during pregnancy causes postpartum cardiac dysfunction and how aspirin prevents it. This project innovates methodologically and at the bench in order to dramatically advance our understanding of a major cause of morbidity and mortality in women globally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $618,303 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	000	5	12/20/2024	NON-COMPETING CONTINUATION	$618,303
														Subtotal = $618,303

Issue Date FY: 2024 ( Subtotal = $673,264 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	000	4	12/14/2023	NON-COMPETING CONTINUATION	$618,303
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	001	4	6/26/2024	NON-COMPETING CONTINUATION	$54,961
														Subtotal = $673,264

Issue Date FY: 2023 ( Subtotal = $687,003 )
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	001	3	12/12/2022	NON-COMPETING CONTINUATION	$618,303
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	002	3	3/6/2023	NON-COMPETING CONTINUATION	$68,700
2023	2022	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	000	2	10/14/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $687,003

Issue Date FY: 2022 ( Subtotal = $1,030,573 )
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	001	2	6/10/2022	NON-COMPETING CONTINUATION	$68,701
2022	2022	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	002	2	9/15/2022	SUPPLEMENT FOR EXPANSION	$343,570
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	000	2	12/14/2021	NON-COMPETING CONTINUATION	$618,302
														Subtotal = $1,030,573

Issue Date FY: 2021 ( Subtotal = $682,510 )
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	000	1	12/24/2020	NEW	$682,510
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cardiovascular Diseases Research	001	1	7/3/2021	NEW	$0
														Subtotal = $682,510

Grand Total All Awards = $3,691,653

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Aspirin to prevent cardiac dysfunction in preeclampsia

Award Number: R01HL148191

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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