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Measuring arterial material properties using wave-based approaches with ultrasound and computational models

Award Number: R01HL145268
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Measuring arterial material properties using wave-based approaches with ultrasound and computational models - ABSTRACT/SUMMARY Background: Increased arterial stiffness has been associated with indicators of damage to the brain including presence of white matter hyperintensity, infarctions, and brain atrophy as assessed with magnetic resonance imaging (MRI). When vessels lose their ability to mechanically absorb the effects of pulsatile flow, that pulsatility is transmitted to the vasculature in the brain leading to deleterious changes in the brain tissue. Understanding the effect of ultrasound measured viscoelastic mechanical properties of central conduit (e.g., carotid) arteries relative to MRI measured brain health indicators could result in a very important tool for predicting and managing changes in brain function. This research project aims to address these unmet and critical needs to develop techniques for the accurate and translatable ultrasound measurement of viscoelastic arterial mechanical properties and evaluate associations with structural changes in the brain. Methods: Ultrasound is a first-line imaging modality for vascular evaluation, but most clinical scanners do not have the ability to evaluate the elastic or viscoelastic mechanical properties of vessels in an accurate, quantitative manner with high temporal resolution. In the first cycle of this grant, we developed an ultrasound- based method called arterial dispersion ultrasound vibrometry (ADUV) that utilizes acoustic radiation force to stimulate high-frequency (200-1500 Hz) waves in the arterial wall, followed by high frame rate ultrasound to measure the wave motion, which is used to characterize arterial viscoelastic mechanical properties. However, our research revealed that several aspects of ADUV could be further improved before being used on a daily basis in the clinic. Among these improvements are increasing the wave motion signal-to-noise ratio, making precise measurements of the vessel geometry with ultrasound, and improving our inversion and classification frameworks. With these improved ADUV methods, we will evaluate how the viscoelastic properties of the carotid artery are associated with the health of the brain as judged using MRI brain morphology data. With the strong collaborative team including expertise in cardiovascular medicine, radiology, ultrasound engineering, waveguide modeling, inverse problems, data reduction and classification, we will bring ADUV closer to widespread translation with the following Specific Aims: Aim 1) Optimize ADUV to enhance motion measurement quality for more accurate and precise mechanical property estimation. Aim 2) Develop advanced mathematical models for estimation of arterial mechanical properties and classification of disease state. Aim 3) Correlate ADUV measurements of carotid artery viscoelasticity with MRI indicators of brain health in patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $616,578 )
2025	2025	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	000	7	2/26/2025	NON-COMPETING CONTINUATION	$616,578
														Subtotal = $616,578

Issue Date FY: 2024 ( Subtotal = $762,105 )
2024	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	004	6	6/24/2024	NON-COMPETING CONTINUATION	$54,810
2024	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	003	6	3/28/2024	NON-COMPETING CONTINUATION	$616,616
2024	2024	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	005	6	7/19/2024	SUPPLEMENT FOR EXPANSION	$90,679
2024	2023	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	002	5	12/20/2023	COMPETING CONTINUATION	$246,679
2024	2022	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	001	4	12/20/2023	SUPPLEMENT FOR EXPANSION	-$23,008
2024	2022	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	000	4	12/20/2023	NON-COMPETING CONTINUATION	-$223,671
														Subtotal = $762,105

Issue Date FY: 2023 ( Subtotal = $709,945 )
2023	2023	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	002	5	4/28/2023	COMPETING CONTINUATION	$8,173
2023	2023	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	001	5	4/14/2023	COMPETING CONTINUATION	$701,772
2023	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	000	4	4/13/2023	NON-COMPETING CONTINUATION	$0
2023	2022	MAYO CLINIC	200 1ST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	003	4	7/10/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $709,945

Issue Date FY: 2022 ( Subtotal = $804,132 )
2022	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	001	4	12/29/2021	SUPPLEMENT FOR EXPANSION	$75,001
2022	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	002	4	1/14/2022	NON-COMPETING CONTINUATION	$15,692
2022	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	000	4	12/25/2021	NON-COMPETING CONTINUATION	$640,528
2022	2022	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	003	4	6/8/2022	NON-COMPETING CONTINUATION	$72,911
														Subtotal = $804,132

Issue Date FY: 2021 ( Subtotal = $828,652 )
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	002	3	4/28/2021	SUPPLEMENT FOR EXPANSION	$15,528
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	000	3	2/19/2021	NON-COMPETING CONTINUATION	$738,901
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	001	3	3/16/2021	SUPPLEMENT FOR EXPANSION	$74,223
2021	2021	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	003	3	5/3/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $828,652

Issue Date FY: 2020 ( Subtotal = $720,989 )
2020	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	000	2	1/10/2020	NON-COMPETING CONTINUATION	$684,939
2020	2020	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	001	2	3/9/2020	NON-COMPETING CONTINUATION	$36,050
														Subtotal = $720,989

Issue Date FY: 2019 ( Subtotal = $754,381 )
2019	2019	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	001	1	1/29/2019	NEW	-$2,899
2019	2019	MAYO CLINIC	200 FIRST ST SW	ROCHESTER	MN	55905	OLMSTED	USA	Cardiovascular Diseases Research	000	1	1/17/2019	NEW	$757,280
														Subtotal = $754,381

Grand Total All Awards = $5,196,782

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Measuring arterial material properties using wave-based approaches with ultrasound and computational models

Award Number: R01HL145268

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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