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The Mechanistic Impact of Paternal Electronic Nicotine Delivery Systems Exposure on Thrombogenesis

Award Number: R01HL145053
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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The Mechanistic Impact of Paternal Electronic Nicotine Delivery Systems Exposure on Thrombogenesis - While the contribution of exposure of future fathers (paternal) to environmental factors, such as smoking, to the pathogenesis of several disease states has been documented, that of Electronic Nicotine Delivery Systems (ENDS), including in the context of occlusive cardiovascular disease (CVD), has not yet been investigated. Therefore, the present application proposes experiments that address fundamental, mechanistic, and clinically relevant translational aspects of the adverse-health effects of ENDS, namely e-waterpipes and e-cigarettes, which are increasingly popular forms of tobacco, in the context of paternal exposure on thrombotic disease and platelet biology. These studies will be performed in a sex-dependent fashion. Specifically, the ramifications of ENDS paternal exposure on normal hemostasis and the development of thrombosis disease will be determined. Subsequent studies will examine whether ENDS modulate platelet function and/or counts. Experiments are also designed to determine the effects of ENDS on the coagulation system and clotting/thrombosis markers. In addition, and in terms of the mechanistic experiments, the role of the platelet transcriptome (e.g., miRnome) of the offspring and the epigenetic marks (e.g., histone modification) of the father’s sperm in mediating ENDS paternal effects will be determined. We will also examine if the development of a proinflammatory and oxidative stress “state” is involved in the observed phenotype. Finally, the impact of paternal ENDS on the placenta will also be investigated. Collectively, these experiments will make significant contributions to the understanding of the consequences of paternal ENDS exposure- an increasingly popular and underappreciated health threat- on cardiovascular health, as well as the mechanism by which it exerts these effects, in a sex-specific manner.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $440,489 )
2025	2025	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Blood Diseases and Resources Research	001	5	5/6/2025	SUPPLEMENT FOR EXPANSION	$769,846
2025	2023	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Blood Diseases and Resources Research	001	5	5/6/2025	SUPPLEMENT FOR EXPANSION	-$73,376
2025	2023	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Blood Diseases and Resources Research	000	5	5/6/2025	NON-COMPETING CONTINUATION	-$255,981
														Subtotal = $440,489

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Blood Diseases and Resources Research	000	5	9/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $487,318 )
2023	2023	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Blood Diseases and Resources Research	000	5	6/19/2023	NON-COMPETING CONTINUATION	$378,750
2023	2023	TEXAS A & M UNIVERSITY SYSTEM HEALTH SCIENCE CENTER	6003 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Blood Diseases and Resources Research	001	5	6/23/2023	SUPPLEMENT FOR EXPANSION	$108,568
														Subtotal = $487,318

Issue Date FY: 2022 ( Subtotal = $518,154 )
2022	2022	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Blood Diseases and Resources Research	001	4	8/2/2022	NON-COMPETING CONTINUATION	$378,750
2022	2022	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Blood Diseases and Resources Research	000	3	4/20/2022	SUPPLEMENT FOR EXPANSION	$30,836
2022	2022	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Blood Diseases and Resources Research	002	4	8/3/2022	SUPPLEMENT FOR EXPANSION	$108,568
														Subtotal = $518,154

Issue Date FY: 2021 ( Subtotal = $378,750 )
2021	2021	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Blood Diseases and Resources Research	002	3	8/4/2021	NON-COMPETING CONTINUATION	$378,750
2021	2020	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Blood Diseases and Resources Research	001	2	1/21/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$329,355
2021	2019	UNIVERSITY OF TEXAS AT EL PASO	500 W UNIVERSITY AVE	EL PASO	TX	79968	EL PASO	USA	Blood Diseases and Resources Research	000	1	1/21/2021	NEW	-$329,355
														Subtotal = $378,750

Issue Date FY: 2020 ( Subtotal = $378,125 )
2020	2020	TEXAS A&M UNIVERSITY SYSTEM, THE	8441 RIVERSIDE PARKWAY BLDG 1 STE 3100	BRYAN	TX	77807	BRAZOS	USA	Blood Diseases and Resources Research	001	2	6/18/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$378,125
2020	2019	UNIVERSITY OF TEXAS AT EL PASO	500 W UNIVERSITY AVE	EL PASO	TX	79968	EL PASO	USA	Blood Diseases and Resources Research	000	1	6/18/2020	NEW	$0
														Subtotal = $378,125

Issue Date FY: 2019 ( Subtotal = $377,500 )
2019	2019	UNIVERSITY OF TEXAS AT EL PASO	500 W UNIVERSITY AVE	EL PASO	TX	79968	EL PASO	USA	Cardiovascular Diseases Research	000	1	6/3/2019	NEW	$377,500
														Subtotal = $377,500

Grand Total All Awards = $2,580,336

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The Mechanistic Impact of Paternal Electronic Nicotine Delivery Systems Exposure on Thrombogenesis

Award Number: R01HL145053

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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