Tuesday, July 1, 2025 7/1/2025

Hypertension Treatment in Nigeria Program

Award Number: R01HL144708
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2030

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Hypertension Treatment in Nigeria Program - PROJECT ABSTRACT This renewal application (R01HL144708) seeks to evaluate and expand upon the successful research conducted during the initial funding period to address the public health impact of hypertension and diabetes in Nigeria. Following a formative research period and based on the WHO ExpandNet framework, we propose to evaluate the effectiveness and implementation of scaling up of the HEARTS multilevel bundle in improving hypertension control in 50 new primary healthcare centers across five states using a type II hybrid study design. We will also evaluate the effect of diabetes service integration through the HEARTS-D bundle on diabetes control and process of implementation into 10 previously enrolled primary healthcare centers in the Federal Capital Territory. The study will explore the sustainment of hypertension services in primary healthcare centers that participated in the initial funding period in the Federal Capital Territory using the DHIS-2 health management information system platform. During the initial funding period, we achieved significant milestones, including: 1) exceeding our recruitment targets, 2) implementing a supportive supervision program and drug revolving fund alongside HEARTS, 3) achieving and sustaining hypertension control rates of >50% for nearly two years, and 4) demonstrating normalization into routine care and high measures of sustainability. The program has become one of the largest hypertension control initiatives in Africa, with impressive results and rigorous assessment methods leading to >10 publications. Through the proposed renewal, we will expand our efforts to Nigeria’s five other geopolitical zones, thus conducting the largest assessment of hypertension care scale-up in Africa. The integration of diabetes services into primary care settings is also a critical focus, given the growing burden of diabetes in Nigeria. We have established, strong collaborations with national, state, and local stakeholders, including government health agencies, policymakers, and healthcare providers. We use contemporary dissemination and implementation science methods, including the WHO ExpandNet framework for scale-up, the Implementation Research Logic Model to assess implementation outcomes, including cost, Normalization Measure Development (NoMAD) to assess normalization into routine care, and the Program Sustainability Assessment Tool (PSAT) to evaluate sustainability beyond the funding period. The renewal period offers an opportunity to advance the field of cardiovascular dissemination and implementation science, while contributing to the knowledge of effective management of non-communicable diseases in primary care settings in a middle-income country setting. This high-impact research has a high likelihood of driving sustained change to improve health outcomes in Nigeria and beyond and is aligned with NHLBI strategic priorities. The University of Abuja will also serve as the primary institution for the renewal, ensuring the program's sustainability beyond the funding period.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $603,656 )
2025	2025	UNIVERSITY OF ABUJA	ORMER 2 MINI CAMPUS, UND ST.	GWAGWALADA				NGA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	6	4/14/2025	COMPETING CONTINUATION	$603,656
														Subtotal = $603,656

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	2/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $646,638 )
2023	2023	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	3/9/2023	NON-COMPETING CONTINUATION	$646,638
2023	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	4	3/9/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$136,492
2023	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	3	3/9/2023	NON-COMPETING CONTINUATION	-$136,492
														Subtotal = $646,638

Issue Date FY: 2022 ( Subtotal = $691,290 )
2022	2022	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	4	9/6/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$691,290
2022	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	9/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $691,290

Issue Date FY: 2021 ( Subtotal = $623,276 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	3/29/2021	NON-COMPETING CONTINUATION	$623,276
														Subtotal = $623,276

Issue Date FY: 2020 ( Subtotal = $623,276 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	5/10/2020	NON-COMPETING CONTINUATION	$623,276
														Subtotal = $623,276

Issue Date FY: 2019 ( Subtotal = $621,216 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	5/10/2019	NEW	$621,216
														Subtotal = $621,216

Grand Total All Awards = $3,809,352

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Hypertension Treatment in Nigeria Program

Award Number: R01HL144708

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2030

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