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MMP-12 as an Endogenous Post-MI Resolution Promoting Factor

Award Number: R01HL137319
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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MMP-12 as an Endogenous Post-MI Resolution Promoting Factor - Abstract About one in four myocardial infarction (MI) patients progress to develop congestive heart failure, which has a 5-year mortality rate of 50%. The goal of this project is to understand post-MI roles of matrix metalloproteinase-12 (MMP-12) by establishing how MMP-12 serves as a resolution promoting factor to stimulate the transition from inflammation to repair. We hypothesize that MMP-12 regulates individual neutrophil, macrophage, and fibroblast physiology to promote the resolution of post-MI inflammation and stimulate repair. Our specific aims will explore the mechanism whereby MMP-12 turns off pro- inflammation (aim 1), initiates anti-inflammation (aim 2), and promotes repair (aim 3). Innovation lies in the evaluation of MMP-12 post-MI to connect early cell functions to late remodeling outcomes and in the integration of multi-discipline approaches to explore the mechanisms whereby MMP-12 regulates resolution. This study will drive forward the understanding of the molecular basis of LV remodeling and will identify novel intervention targets directed at MMP-12.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$82,713 )
2023	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	000	4	7/20/2023	NON-COMPETING CONTINUATION	-$82,713
														Subtotal = -$82,713

Issue Date FY: 2022 ( Subtotal = $381,250 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	001	4	6/9/2022	NON-COMPETING CONTINUATION	$38,125
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	000	4	1/13/2022	NON-COMPETING CONTINUATION	$343,125
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	002	4	9/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $381,250

Issue Date FY: 2021 ( Subtotal = $381,250 )
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	001	3	5/24/2021	NON-COMPETING CONTINUATION	$38,125
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	000	3	1/11/2021	NON-COMPETING CONTINUATION	$343,125
														Subtotal = $381,250

Issue Date FY: 2020 ( Subtotal = $381,250 )
2020	2020	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	000	2	1/22/2020	NON-COMPETING CONTINUATION	$381,250
														Subtotal = $381,250

Issue Date FY: 2019 ( Subtotal = $381,250 )
2019	2019	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cardiovascular Diseases Research	000	1	1/15/2019	NEW	$381,250
														Subtotal = $381,250

Grand Total All Awards = $1,442,287

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MMP-12 as an Endogenous Post-MI Resolution Promoting Factor

Award Number: R01HL137319

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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