Friday, October 22, 2021
10/22/2021
Abstract About one in four myocardial infarction (MI) patients progress to develop congestive heart failure, which has a 5-year mortality rate of 50%. The goal of this project is to understand post-MI roles of matrix metalloproteinase-12 (MMP-12) by establishing how MMP-12 serves as a resolution promoting factor to stimulate the transition from inflammation to repair. We hypothesize that MMP-12 regulates individual neutrophil, macrophage, and fibroblast physiology to promote the resolution of post-MI inflammation and stimulate repair. Our specific aims will explore the mechanism whereby MMP-12 turns off pro- inflammation (aim 1), initiates anti-inflammation (aim 2), and promotes repair (aim 3). Innovation lies in the evaluation of MMP-12 post-MI to connect early cell functions to late remodeling outcomes and in the integration of multi-discipline approaches to explore the mechanisms whereby MMP-12 regulates resolution. This study will drive forward the understanding of the molecular basis of LV remodeling and will identify novel intervention targets directed at MMP-12.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
