Wednesday, January 7, 2026 1/7/2026

The Penn State Child Sleep Cohort: Cardiometabolic and Neurocognitive Risk in Young Adulthood

Award Number: R01HL136587
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/25/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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The Penn State Child Sleep Cohort: Cardiometabolic and Neurocognitive Risk in Young Adulthood - PROJECT SUMMARY Adolescence is a critical period for normal, healthy development but also for the onset of significant health problems, including those related to the obesity epidemic such as sleep disordered breathing (SDB). While obesity is highly persistent since childhood, the natural course of childhood SDB is remission in the transition to adolescence. However, the incidence of SDB dramatically increases in adolescence and cohort studies in adults have shown that the association of SDB with adverse cardiometabolic and neurocognitive outcomes is strongest in young adults (20-30y). We hypothesize that the impact of obesity and SDB on adverse health outcomes in young adults is a consequence of their chronic course in the transition from adolescence. From a mechanistic perspective, however, the association of obesity and SDB with these adverse health outcomes remains poorly understood. Likely candidates, beyond standard measures such as waist circumference or number of apneas/hypopneas during sleep, are chronic low-grade inflammation and activation of both limbs of the stress system. There are no prospective studies examining the impact and underlying mechanisms of adolescent obesity and SDB on adverse health outcomes in young adulthood. We propose to conduct a follow- up examination of the Penn State Child Cohort (PSCC), a population-based sample of children who were 5-12 years old at baseline (visit 1) and 12-23 years old at their previous follow-up (visit 2). The overall objective is to prospectively assess the subclinical and clinical consequences of adolescent SDB and obesity and their underlying systemic (immune and stress) mechanisms and lifestyle risk factors. Specifically, we propose to 1) Detail the natural history of SDB in the transition between adolescence and young adulthood and establish its key determinant, focusing on visceral adiposity independent of body mass index percentile; 2) Test the longitudinal association between adolescent SDB with adverse cardiometabolic and neurocognitive outcomes in young adulthood and its underlying immune- and stress-related mechanisms; and 3) Test the longitudinal association between adolescent visceral obesity, independent of SDB, with cardiometabolic and neurocognitive outcomes in young adulthood via systemic mechanisms and novel circadian- and sleep-related lifestyle risk factors. This innovative, transdisciplinary paradigm will fill the gap in current knowledge of the underlying mechanisms playing a key role in the association of adolescent SDB and obesity with adverse health outcomes in young adulthood, while testing two non-mutually exclusive mechanisms as they relate to systemic dysregulation and lifestyle factors. The potential for circadian and sleep disorders to play a role in the association of obesity, a public health problem of epidemic proportions, with adverse health outcomes makes this proposal translational to public health and clinical interventions, as most of the factors and mechanisms explored herein are modifiable. Early prevention at the onset of these highly chronic conditions needs to be supported by a thorough understanding of lifestyle and biological mechanisms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$51,997 )
2026	2022	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	National Center on Sleep Disorders Research	000	5	12/30/2025	NON-COMPETING CONTINUATION	-$51,997
														Subtotal = -$51,997

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	PENNSYLVANIA STATE UNIVERSITY	500 UNIVERSITY DRIVE	HERSHEY	PA	17033	DAUPHIN	USA	National Center on Sleep Disorders Research	000	5	5/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $704,894 )
2022	2022	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY AVE RM C1607	HERSHEY	PA	17033	DAUPHIN	USA	National Center on Sleep Disorders Research	000	5	6/18/2022	NON-COMPETING CONTINUATION	$704,894
														Subtotal = $704,894

Issue Date FY: 2021 ( Subtotal = $724,807 )
2021	2021	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY AVE RM C1607	HERSHEY	PA	17033	DAUPHIN	USA	National Center on Sleep Disorders Research	000	4	7/1/2021	NON-COMPETING CONTINUATION	$724,807
														Subtotal = $724,807

Issue Date FY: 2020 ( Subtotal = $738,226 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	National Center on Sleep Disorders Research	000	3	6/30/2020	NON-COMPETING CONTINUATION	$738,226
														Subtotal = $738,226

Issue Date FY: 2019 ( Subtotal = $749,139 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	National Center on Sleep Disorders Research	000	2	7/1/2019	NON-COMPETING CONTINUATION	$749,139
														Subtotal = $749,139

Issue Date FY: 2018 ( Subtotal = $756,188 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	500 UNIVERSITY DR C1607	HERSHEY	PA	17033	DAUPHIN	USA	National Center on Sleep Disorders Research	000	1	8/29/2018	NEW	$756,188
														Subtotal = $756,188

Grand Total All Awards = $3,621,257

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The Penn State Child Sleep Cohort: Cardiometabolic and Neurocognitive Risk in Young Adulthood

Award Number: R01HL136587

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/25/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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