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Incorporation of a Hypertension Working Group into the Jackson Heart Study

Award Number: R01HL117323
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2013
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Incorporation of a Hypertension Working Group into the Jackson Heart Study - Studying hypertension in adults at high risk for it in 2020 is more important than ever. Recent findings show that 54% of African American adults have hypertension, but only 19% have their blood pressure (BP) controlled to recommended levels, and elevated BP and hypertension account for 33% of cardiovascular disease (CVD) events among African Americans. The 2030 American Heart Association (AHA) impact goal is to increase the health-adjusted life expectancy of US adults by 3 years over the next decade. Health-adjusted life expectancy is shorter in African Americans and our preliminary data from the Jackson Heart Study (JHS) indicates its 7 years shorter among African American adults with versus without hypertension. In this application, we propose the renewal of the JHS Hypertension Working Group (JHS–HWG), which will address new high priority BP research questions in African Americans and also serve to mentor early-stage investigators (ESIs) in hypertension research. Given its large sample size and extensive phenotyping, the JHS is the ideal setting for addressing several knowledge gaps in hypertension among African Americans. Between 2000 and 2004, 5,306 African Americans were enrolled in the JHS, providing an unique opportunity to study hypertension within this high-risk population, while also generating insights relevant to the broader population at risk for hypertension and related morbidity. Three study visits have assessed hypertension onset and organ damage, and over 16 years follow-up for CVD events. Over the past two funding cycles (7 years), 30 JHS-HWG ESIs, have published 48 manuscripts with 6 manuscripts undergoing peer review. JHS-HWG ESIs have successfully obtained grant funding including four R01 awards, seven career development awards (six NIH and one AHA), and one pre-doctoral F31 award. For the next grant cycle, we propose to conduct research in four core thematic areas: (1) individual and community level health factors and risk for hypertension and BP control; (2) health behaviors and risk for hypertension and BP control; (3) assess generalizability of findings from JHS to other high risk populations with existing datasets; and (4) impact hypertension prevention and BP control on increasing health adjusted life expectancy. New training activities for ESIs include an introduction to interdisciplinary team science, career development planning, grant writing workshops, group peer mentoring, and writing accountability groups. Also, we will provide career training for former JHS-HWG ESIs that are now mid-career. The JHS-HWG will be led by principal investigators who have a strong collaborative history, and an established track record of publishing high impact hypertension research and mentoring ESIs. Through the JHS-HWG, we aim to identify approaches to prevent hypertension, improve BP control and increase health-adjusted life expectancy while providing innovative training and career development opportunities for the next generation of hypertension researchers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	11	9/23/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $704,406 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	11	8/6/2024	NON-COMPETING CONTINUATION	$704,406
														Subtotal = $704,406

Issue Date FY: 2023 ( Subtotal = $725,465 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	10	7/28/2023	NON-COMPETING CONTINUATION	$725,465
														Subtotal = $725,465

Issue Date FY: 2022 ( Subtotal = $734,894 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	003	9	8/10/2022	NON-COMPETING CONTINUATION	$734,894
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	002	8	11/12/2021	COMPETING CONTINUATION	$977,903
2022	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	7	11/12/2021	NON-COMPETING CONTINUATION	-$733,061
2022	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	6	11/12/2021	NON-COMPETING CONTINUATION	-$244,842
														Subtotal = $734,894

Issue Date FY: 2021 ( Subtotal = $735,152 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	8	6/27/2021	COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	8	4/28/2021	COMPETING CONTINUATION	$735,152
														Subtotal = $735,152

Issue Date FY: 2020 ( Subtotal = $733,061 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	7	6/18/2020	NON-COMPETING CONTINUATION	$733,061
														Subtotal = $733,061

Issue Date FY: 2019 ( Subtotal = $745,170 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	6	6/12/2019	NON-COMPETING CONTINUATION	$745,170
														Subtotal = $745,170

Issue Date FY: 2018 ( Subtotal = $761,965 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	002	5	7/12/2018	NON-COMPETING CONTINUATION	$761,965
2018	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	4	11/20/2017	COMPETING CONTINUATION	$183,320
2018	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	3	11/20/2017	NON-COMPETING CONTINUATION	-$183,320
														Subtotal = $761,965

Issue Date FY: 2017 ( Subtotal = $796,739 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	4	5/26/2017	COMPETING CONTINUATION	$796,739
														Subtotal = $796,739

Issue Date FY: 2015 ( Subtotal = $475,365 )
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	002	3	7/23/2015	NON-COMPETING CONTINUATION	$0
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	3	6/4/2015	NON-COMPETING CONTINUATION	$475,365
2015	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	2	12/1/2014	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $475,365

Issue Date FY: 2014 ( Subtotal = $482,009 )
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	2	6/5/2014	NON-COMPETING CONTINUATION	$325,376
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	002	2	9/9/2014	SUPPLEMENT FOR EXPANSION	$104,320
2014	2014	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	2	9/8/2014	SUPPLEMENT FOR EXPANSION	$52,313
														Subtotal = $482,009

Issue Date FY: 2013 ( Subtotal = $335,014 )
2013	2013	UNIVERSITY OF ALABAMA AT BIRMINGHAM	UAB STATION, CBB 990	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	1	7/15/2013	NEW	$335,014
														Subtotal = $335,014

Grand Total All Awards = $7,229,240

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Incorporation of a Hypertension Working Group into the Jackson Heart Study

Award Number: R01HL117323

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2013

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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