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Translation Studie of the Planet Specific Receptor Trem Like Transcript (TLT)

Award Number: R01HL090933
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary According to the World Health Organization, Cardiovascular disease (CVD) is responsible for 31% of deaths worldwide making it the largest global cause of mortality. These numbers are reflected in the United states where over 600,000 people died of CVD. CVD is an inflammatory disease that often leads to mortality by thrombosis and platelets mediate both the inflammatory and thrombotic aspects of CVD. Our laboratory studies the Triggering receptor expressed in myeloid cells or (TLT-1) that is stored in the granules of the platelets and is both expressed to the platelet surface and released after platelet activation. TLT-1 binds fibrinogen. While TLT-1 has demonstrated roles in Cardiovascular disease, sepsis, and acute lung injury, its interaction with fibrinogen is poorly understood. We hypothesize that TLT-1’s interaction with fibrinogen is a major pathway by which the immune system commandeers the hemostatic system for immune function. In this application we propose to mechanistically define this interaction and demonstrate is usefulness as a therapeutic target. We propose the following three aims: Aim I – Determine the relative contribution of fibrinogen binding to TLT-1 and IIb2 using double deficient (treml1-/-/itga2b-/-) mice; Aim II - Elucidate TLT-1 signaling pathways; Aim III – Evaluate the effect of TLT-1 prophylactics on the progression of CVD and obesity. At the completion of these aims we will have defined TLT-1’s contribution to platelet interaction with fibrinogen and is potential as a therapeutic target.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	OAKLAND UNIVERSITY	2200 N SQUIRREL RD	ROCHESTER	MI	48309	OAKLAND	USA	Blood Diseases and Resources Research	000	9	7/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	003	7	1/4/2023	SUPPLEMENT FOR EXPANSION	-$46,695
2023	2021	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	001	7	11/22/2022	SUPPLEMENT FOR EXPANSION	$0
2023	2021	OAKLAND UNIVERSITY	2200 N SQUIRREL RD	ROCHESTER	MI	48309	OAKLAND	USA	Blood Diseases and Resources Research	004	8	1/4/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$387,615
2023	2020	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	7	11/21/2022	NON-COMPETING CONTINUATION	$0
2023	2020	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	002	7	1/4/2023	NON-COMPETING CONTINUATION	-$340,920
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $366,835 )
2022	2022	OAKLAND UNIVERSITY	2200 N SQUIRREL RD	ROCHESTER	MI	48309	OAKLAND	USA	Blood Diseases and Resources Research	000	9	7/7/2022	NON-COMPETING CONTINUATION	$366,835
														Subtotal = $366,835

Issue Date FY: 2021 ( Subtotal = $490,107 )
2021	2021	OAKLAND UNIVERSITY	2200 N SQUIRREL RD	ROCHESTER	MI	48309	OAKLAND	USA	Blood Diseases and Resources Research	003	8	9/17/2021	SUPPLEMENT FOR EXPANSION	$74,500
2021	2021	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	7	1/22/2021	SUPPLEMENT FOR EXPANSION	$46,695
2021	2021	OAKLAND UNIVERSITY	2200 N SQUIRREL RD	ROCHESTER	MI	48309	OAKLAND	USA	Blood Diseases and Resources Research	002	8	8/25/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$368,912
2021	2020	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	001	7	8/20/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $490,107

Issue Date FY: 2020 ( Subtotal = $372,500 )
2020	2020	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	7	6/9/2020	NON-COMPETING CONTINUATION	$372,500
														Subtotal = $372,500

Issue Date FY: 2019 ( Subtotal = $369,070 )
2019	2019	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	000	6	8/15/2019	COMPETING CONTINUATION	$369,070
														Subtotal = $369,070

Issue Date FY: 2017 ( Subtotal = -$11,337 )
2017	2015	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	002	5	8/4/2017	NON-COMPETING CONTINUATION	-$11,337
2017	2013	UNIVERSITY OF PUERTO RICO	39 PONCE DE LEON AVE	SAN JUAN	PR	00931	SAN JUAN	USA	Blood Diseases and Resources Research	001	3	1/27/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$4,046
2017	2012	UNIVERSIDAD CENTRAL DEL CARIBE INC	AVE LAUREL URB SANTA JUANITA	BAYAMON	PR	00956	BAYAMON	USA	Blood Diseases and Resources Research	000	2	1/27/2017	NON-COMPETING CONTINUATION	-$4,046
														Subtotal = -$11,337

Issue Date FY: 2015 ( Subtotal = $259,414 )
2015	2015	UNIVERSITY OF PUERTO RICO, RIO PIEDRAS CAMPUS	PO BOX 21790	SAN JUAN	PR			USA	Blood Diseases and Resources Research	000	5	3/30/2015	NON-COMPETING CONTINUATION	$259,414
														Subtotal = $259,414

Issue Date FY: 2014 ( Subtotal = $258,098 )
2014	2014	UNIVERSITY OF PUERTO RICO, RIO PIEDRAS CAMPUS	PO BOX 21790	SAN JUAN	PR			USA	Blood Diseases and Resources Research	000	4	3/27/2014	NON-COMPETING CONTINUATION	$258,098
														Subtotal = $258,098

Issue Date FY: 2013 ( Subtotal = $250,723 )
2013	2013	UNIVERSITY OF PUERTO RICO, RIO PIEDRAS CAMPUS	PO BOX 23308	SAN JUAN	PR			USA	Blood Diseases and Resources Research	002	3	6/28/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$13,694
2013	2013	UNIVERSITY OF PUERTO RICO, RIO PIEDRAS CAMPUS	PO BOX 23308	SAN JUAN	PR			USA	Blood Diseases and Resources Research	001	3	4/30/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$237,029
2013	2012	UNIVERSIDAD CENTRAL DEL CARIBE ESCUELA DE MED DE CAYEY	POST OFFICE BOX 60-327	BAYAMON	PR	00960	BAYAMON	USA	Blood Diseases and Resources Research	000	2	4/30/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $250,723

Issue Date FY: 2012 ( Subtotal = $263,573 )
2012	2012	UNIVERSIDAD CENTRAL DEL CARIBE ESCUELA DE MED DE CAYEY	POST OFFICE BOX 60-327	BAYAMON	PR			USA	Blood Diseases and Resources Research	000	2	4/23/2012	NON-COMPETING CONTINUATION	$263,573
														Subtotal = $263,573

Issue Date FY: 2011 ( Subtotal = $262,456 )
2011	2011	UNIVERSIDAD CENTRAL DEL CARIBE ESCUELA DE MED DE CAYEY	POST OFFICE BOX 60-327	BAYAMON	PR			USA	Blood Diseases and Resources Research	000	1	6/16/2011	NEW	$262,456
														Subtotal = $262,456

Grand Total All Awards = $2,881,439

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Translation Studie of the Planet Specific Receptor Trem Like Transcript (TLT)

Award Number: R01HL090933

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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