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BIOSENSOR CHIP FOR VENOUS THROMBOEMBOLISM GENOTYPING

Award Number: R01HL075114
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2004
PERIOD OF PERFORMANCE END DATE: 08/31/2009

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BIOSENSOR CHIP FOR VENOUS THROMBOEMBOLISM GENOTYPING - DESCRIPTION (provided by applicant): Our hypothesis is that important genetic factors that contribute to VTE risk have not yet been identified, particularly within the African American (AA) population. We propose to utilize a novel, inexpensive optical biosensor assay for screening multiple single nucleotide polymorphisms (SNPs) or Indels (short insertions/deletions) simultaneously in samples made available through collaboration with Drs. Richard Marlar and Carolyn Welsh in order to identify such genetic factors. Both a case/control population (700 cases; 1,400 controls) and families (410) with Hereditary Thrombolic Disorder (HTD) will be used in these studies. The relative contribution of individual or multiple polymorphisms inherited simultaneously on VTE risk will be statistically assessed by our biostatistician, Dr. Hongyu Zhao. SNPs that have been reported to contribute to VTE, and SNPs that are in promoter regions or create nonconservative amino acid substitutions in genes associated with coagulation homeostasis will be analyzed. The extensive set of new genetic data will be incorporated into the VA Merit Review study of acquired and physiological VTE risk factors and collective risk parameters assessed in collaboration with Dr. Marlar and his associates. We propose to focus additional work on analysis of VTE in African American (AA) cases, both individuals from the 34 AA families from the HTD family study and AA individuals from the case/control study. These samples will be analyzed by admixture mapping to identify genomic regions containing disease related alleles that are present in the African genome and of lower abundance or absent in the European. This will be followed by analysis of VTE associated gene haplotypes in the AA VTE families and AA individuals in the case/control study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	Nevada Cancer Institute	STE 260	IAS VEGAS	NV	89135		USA	Blood Diseases and Resources Research	000	4	2/3/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $320,985 )
2007	2007	Nevada Cancer Institute	STE 260	IAS VEGAS	NV	89135		USA	Blood Diseases and Resources Research	000	4	8/1/2007	NON-COMPETING CONTINUATION	$320,985
														Subtotal = $320,985

Issue Date FY: 2006 ( Subtotal = $330,573 )
2006	2006	Nevada Cancer Institute	STE 260	IAS VEGAS	NV	89135		USA	Blood Diseases and Resources Research	000	3	8/17/2006	NON-COMPETING CONTINUATION	$330,573
														Subtotal = $330,573

Issue Date FY: 2005 ( Subtotal = $338,528 )
2005	2005	Nevada Cancer Institute	STE 260	IAS VEGAS	NV	89135		USA	Blood Diseases and Resources Research	000	2	9/5/2005	NON-COMPETING CONTINUATION	$338,528
														Subtotal = $338,528

Issue Date FY: 2004 ( Subtotal = $358,997 )
2004	2004	Nevada Cancer Institute	STE 260	IAS VEGAS	NV	89135		USA	Blood Diseases and Resources Research	000	1	9/9/2004	NEW	$358,997
														Subtotal = $358,997

Grand Total All Awards = $1,349,083

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BIOSENSOR CHIP FOR VENOUS THROMBOEMBOLISM GENOTYPING

Award Number: R01HL075114

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2004

PERIOD OF PERFORMANCE END DATE: 08/31/2009

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