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Effect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular Reactivity

Award Number: R01HL046716
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Effect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular Reactivity - SUMMARY: Cardiac surgery, especially that involving cardioplegia (CP) and cardiopulmonary bypass (CPB), is associated with significant changes in vasomotor regulation and subsequent organ injury such as neurocognitive deficit, stroke, renal and mesenteric failure, post-operative systemic hypotension and coronary spasm. Hypertension is also associated with severe autonomic dysfunction and vasomotor regulation, as well as with increased morbidity and mortality after surgical procedures. The goal of the proposed research is to determine the effect of well-controlled and poorly controlled hypertension on alterations in vascular signal transduction and function and to investigate the changes that occur in these patients before and after undergoing heart surgery with CP and CPB. Specifically, hypertension-related differences in microvascular function will be investigated with specific focus on 1) myogenic tone, 2) -adrenergic and vasopressin-induced microvascular signaling and contraction, 3) and the differential effects of gender and aging on myogenic, angiotensin I and II, and -adrenergic pathway. These aims will be examined in the microvasculature of well- controlled and poorly controlled hypertensive and age-matched normotensive patients, using in vitro microvascular imaging. This work will be accomplished through an exhaustive approach using molecular and cellular biology techniques to examine gene and protein expression and activation involved in maintaining vascular integrity and signaling following cardiac surgery. The results of these studies may have significant implications regarding the recovery of hypertensive and other patients after cardiac surgery.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	29	2/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $611,958 )
2023	2023	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	29	4/24/2023	NON-COMPETING CONTINUATION	$611,958
														Subtotal = $611,958

Issue Date FY: 2022 ( Subtotal = $611,958 )
2022	2022	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	001	28	5/31/2022	NON-COMPETING CONTINUATION	$61,196
2022	2022	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	28	3/18/2022	NON-COMPETING CONTINUATION	$550,762
														Subtotal = $611,958

Issue Date FY: 2021 ( Subtotal = $611,958 )
2021	2021	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	002	27	3/11/2021	NON-COMPETING CONTINUATION	$611,958
2021	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	001	26	2/20/2021	COMPETING CONTINUATION	$75,462
2021	2018	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	25	2/20/2021	NON-COMPETING CONTINUATION	-$75,462
														Subtotal = $611,958

Issue Date FY: 2020 ( Subtotal = $631,958 )
2020	2020	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	002	26	4/6/2020	COMPETING CONTINUATION	$631,958
2020	2018	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	001	25	4/3/2020	NON-COMPETING CONTINUATION	$0
2020	2018	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	25	2/12/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $631,958

Issue Date FY: 2018 ( Subtotal = $385,876 )
2018	2018	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	25	3/21/2018	NON-COMPETING CONTINUATION	$378,158
2018	2018	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	001	25	7/7/2018	NON-COMPETING CONTINUATION	$7,718
														Subtotal = $385,876

Issue Date FY: 2017 ( Subtotal = $385,876 )
2017	2017	RHODE ISLAND HOSPITAL	593 EDDY ST	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	24	3/31/2017	NON-COMPETING CONTINUATION	$385,876
														Subtotal = $385,876

Issue Date FY: 2016 ( Subtotal = $385,876 )
2016	2016	RHODE ISLAND HOSPITAL	593 EDDY ST, ALDRICH 317	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	23	4/2/2016	NON-COMPETING CONTINUATION	$385,876
														Subtotal = $385,876

Issue Date FY: 2015 ( Subtotal = $385,876 )
2015	2015	RHODE ISLAND HOSPITAL	593 EDDY ST, ALDRICH 317	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	001	22	8/21/2015	COMPETING CONTINUATION	$385,876
2015	2013	RHODE ISLAND HOSPITAL	593 EDDY ST, ALDRICH 317	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	21	4/1/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $385,876

Issue Date FY: 2013 ( Subtotal = $364,033 )
2013	2013	RHODE ISLAND HOSPITAL	593 EDDY ST, ALDRICH 317	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	21	5/31/2013	NON-COMPETING CONTINUATION	$364,033
														Subtotal = $364,033

Issue Date FY: 2012 ( Subtotal = $382,388 )
2012	2012	RHODE ISLAND HOSPITAL	593 EDDY ST, ALDRICH 317	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	20	5/22/2012	NON-COMPETING CONTINUATION	$382,388
														Subtotal = $382,388

Issue Date FY: 2011 ( Subtotal = $386,250 )
2011	2011	RHODE ISLAND HOSPITAL	593 EDDY ST, ALDRICH 317	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	000	19	5/27/2011	NON-COMPETING CONTINUATION	$386,250
														Subtotal = $386,250

Issue Date FY: 2010 ( Subtotal = $386,250 )
2010	2010	RHODE ISLAND HOSPITAL	593 EDDY ST, ALDRICH 317	PROVIDENCE	RI	02903	PROVIDENCE	USA	Cardiovascular Diseases Research	001	18	5/20/2010	COMPETING CONTINUATION	$386,250
2010	2009	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	000	17	5/18/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $386,250

Issue Date FY: 2009 ( Subtotal = $330,140 )
2009	2009	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02215	SUFFOLK	USA	Cardiovascular Diseases Research	000	17	11/24/2008	NON-COMPETING CONTINUATION	$330,140
														Subtotal = $330,140

Issue Date FY: 2008 ( Subtotal = $330,140 )
2008	2008	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	000	16	12/4/2007	NON-COMPETING CONTINUATION	$330,140
														Subtotal = $330,140

Issue Date FY: 2007 ( Subtotal = $368,798 )
2007	2007	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	000	15	12/4/2006	NON-COMPETING CONTINUATION	$368,798
														Subtotal = $368,798

Issue Date FY: 2006 ( Subtotal = $397,313 )
2006	2006	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	000	14	12/31/2005	COMPETING CONTINUATION	$397,313
														Subtotal = $397,313

Issue Date FY: 2004 ( Subtotal = $297,500 )
2004	2004	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	000	13	7/6/2004	NON-COMPETING CONTINUATION	$297,500
														Subtotal = $297,500

Issue Date FY: 2003 ( Subtotal = $297,500 )
2003	2003	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	000	12	7/16/2003	NON-COMPETING CONTINUATION	$297,500
														Subtotal = $297,500

Issue Date FY: 2002 ( Subtotal = $372,439 )
2002	2002	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	000	11	7/24/2002	NON-COMPETING CONTINUATION	$297,500
2002	2002	BETH ISRAEL HOSPITAL	330 BROOKLINE AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	001	11	8/13/2002	SUPPLEMENT FOR EXPANSION	$74,939
														Subtotal = $372,439

Issue Date FY: 2001 ( Subtotal = $297,500 ) (Continued on the next page)
Grand Total All Awards = $8,969,191

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Effect of Cardioplegia and Cardiopulmonary Bypass on Coronary Microvascular Reactivity

Award Number: R01HL046716

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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