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MFB: Fluidics system for efficient site-specific labeling of RNAs

Award Number: R01HG013861
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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MFB: Fluidics system for efficient site-specific labeling of RNAs - PPROJECT SUMMARY (See instructions): mRNA in cells contains base modifications, strategically (and dynamically) placed at specific position in the RNA. For fundamental research, RNA containing site-specific modifications can be generated by chemical synthesis, but only at very short lengths. The proposed research aims to build on recent advances in co-immobilized flow transcription to develop an enzymatic system to incorporate (multiple and different) modified bases site-specifically. Such a system would enable more detailed studies of translation and alternative splicing, for example, where base modifications are known to play key roles. Synthesis of RNA with position-specific substitutions will also facilitate studies of RNA structure and dynamics, where fluorescent probes for FRET/environment studies or stable isotopes for NMR measurements are essential. A better understanding of the roles of specific base modifications will ultimately inform future RNA therapeutics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $422,039 )
2026	2026	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Human Genome Research	000	3	5/25/2026	NON-COMPETING CONTINUATION	$422,039
														Subtotal = $422,039

Issue Date FY: 2025 ( Subtotal = $421,618 )
2025	2025	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Human Genome Research	001	2	4/30/2025	NON-COMPETING CONTINUATION	$42,162
2025	2025	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Human Genome Research	000	2	4/16/2025	NON-COMPETING CONTINUATION	$379,456
														Subtotal = $421,618

Issue Date FY: 2024 ( Subtotal = $413,250 )
2024	2024	UNIVERSITY OF MASSACHUSETTS	101 COMMONWEALTH AVE	AMHERST	MA	01003	HAMPSHIRE	USA	Human Genome Research	000	1	6/24/2024	NEW	$413,250
														Subtotal = $413,250

Grand Total All Awards = $1,256,907

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MFB: Fluidics system for efficient site-specific labeling of RNAs

Award Number: R01HG013861

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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