Sunday, February 15, 2026 2/15/2026

Beyond the Medical: The ELSI of Polygenic Scores for Social Traits

Award Number: R01HG012402
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/13/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

Group Awards By:

View Award Description

Beyond the Medical: The ELSI of Polygenic Scores for Social Traits - 7. PROJECT SUMMARY/ ABSTRACT In traditional predictive genetic testing single gene variants are analyzed to determine whether an individual is at high risk of developing a disease. The vast majority of diseases, however, are polygenic—caused by many different genes. Polygenic risk scores (PRS) have been heralded for their promise to predict risk for these more complex diseases like heart disease or diabetes by measuring the contribution of hundreds or thousands of genetic variants at once. Yet beyond prediction of health or medical outcomes, the realm of `sociogenomics' is developing polygenic scores (PGS) measuring genetic contributions to social traits and behavioral factors, such as income, educational attainment, sexuality, and optimism. Proponents of sociogenomic PGS cite the potential for this research to increase understanding of the interplay between genetic and environmental factors, to account for genetic factors in social science research, and to create personalized social interventions akin to personalized medicine. But others worry that sociogenomic PGS findings could lead to discrimination and an exacerbation of existing social disparities. In order to understand the ethical, legal, and social implications of sociogenomic PGS research and its outcomes, this project addresses the following research questions: 1) What are the current trends in the development of sociogenomic PGS and what are the possible applications of scores in social settings?; 2) How do various stakeholders perceive the benefits and risks of sociogenomic PGS?; and 3) How well do existing laws, policies, or governance protect against the potential harms of sociogenomic PGS while also promoting their potential benefits? Answering these questions requires both empirical research and legal analysis. Using horizon scanning methodologies, Aim 1 maps the landscape of sociogenomic PGS, their potential applications, and how sociogenomic research findings are presented to and consumed by the public. Aim 2 enlists those involved in the pipeline of sociogenomics research (biobank participants whose genetic data may be used to develop PGS, PGS researchers who develop the scores, and social scientists who may use the scores in their research studies) to examine and assess their attitudes toward the range of harms and benefits of sociogenomic PGS, and the implications of varying applications of PGS. Both of these efforts will inform Aim 3, which consists of a legal and policy analysis of how current legal rules protect against potential misuse and/or promote possible benefits of sociogenomic findings. The product of this project will be a set of case studies designed to help policy makers and researchers anticipate and mitigate the potential harms of employing sociogenomic PGS in various social settings while still identifying and maximizing potential benefits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Human Genome Research	000	4	1/6/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $626,993 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Human Genome Research	000	4	5/14/2025	NON-COMPETING CONTINUATION	$626,993
														Subtotal = $626,993

Issue Date FY: 2024 ( Subtotal = $670,843 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Human Genome Research	000	3	3/21/2024	NON-COMPETING CONTINUATION	$616,080
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Human Genome Research	001	3	7/17/2024	NON-COMPETING CONTINUATION	$54,763
														Subtotal = $670,843

Issue Date FY: 2023 ( Subtotal = $716,784 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Human Genome Research	000	2	3/15/2023	NON-COMPETING CONTINUATION	$716,784
														Subtotal = $716,784

Issue Date FY: 2022 ( Subtotal = $711,500 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Human Genome Research	000	1	6/13/2022	NEW	$711,500
														Subtotal = $711,500

Grand Total All Awards = $2,726,120

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Beyond the Medical: The ELSI of Polygenic Scores for Social Traits

Award Number: R01HG012402

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/13/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer