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A platform for scalable spatial single cell genomics

Award Number: R01HG010647
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/08/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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A platform for scalable spatial single cell genomics - SUMMARY The function of human tissues is dependent upon complex interactions amongst millions of substituent cells. Tools that can systematically measure transcriptional and epigenetic states of these cells, while also recording their spatial positions, hold great promise in understanding both normal tissue function and its dysfunction in disease conditions. In this proposal, we build upon our recent invention of Slide-tags, a single-cell spatial genomics technology, to enable facile, spatial profiling of millions of cells across surface areas spanning tens of centimeters. We will extend Slide-tags to measure not only transcription, but also epigenetic states and genome variation within individual cells. Further, we will make Slide-tags profiling compatible with fixed and paraffin- embedded tissues. The innovations from this project will yield a robust, multiomic spatial platform for the routine profiling of human tissues at the scale of entire organs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $682,271 )
2026	2026	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	000	7	5/14/2026	NON-COMPETING CONTINUATION	$682,271
														Subtotal = $682,271

Issue Date FY: 2025 ( Subtotal = $682,271 )
2025	2025	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	000	6	5/13/2025	NON-COMPETING CONTINUATION	$682,271
														Subtotal = $682,271

Issue Date FY: 2024 ( Subtotal = $678,553 )
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	001	5	7/15/2024	COMPETING CONTINUATION	$682,271
2024	2022	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	000	4	12/18/2023	NON-COMPETING CONTINUATION	-$3,718
														Subtotal = $678,553

Issue Date FY: 2022 ( Subtotal = $946,363 )
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	000	4	6/3/2022	NON-COMPETING CONTINUATION	$946,363
														Subtotal = $946,363

Issue Date FY: 2021 ( Subtotal = $946,363 )
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	000	3	5/20/2021	NON-COMPETING CONTINUATION	$946,363
														Subtotal = $946,363

Issue Date FY: 2020 ( Subtotal = $1,120,100 )
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	000	2	5/21/2020	NON-COMPETING CONTINUATION	$946,363
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	001	2	8/7/2020	SUPPLEMENT FOR EXPANSION	$173,737
														Subtotal = $1,120,100

Issue Date FY: 2019 ( Subtotal = $946,363 )
2019	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Human Genome Research	000	1	8/8/2019	NEW	$946,363
														Subtotal = $946,363

Grand Total All Awards = $6,002,284

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A platform for scalable spatial single cell genomics

Award Number: R01HG010647

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/08/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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