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A Longitudinal Study of Adversity, Stress Processes, and Health from Adolescence to Young Adulthood

Award Number: R01HD106650
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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A Longitudinal Study of Adversity, Stress Processes, and Health from Adolescence to Young Adulthood - Abstract Serious stress-related public health concerns exist for today’s Latin American-origin youth. Chronic and/or severe exposure to adversity can elevate stress processes in the family (e.g., increased maternal depression) and manifest through youth’s behavioral health (e.g., unhealthy diet), and biology (e.g., flatter diurnal slopes of daily cortisol output). These stress processes can increase mental health and chronic disease risks and limit social mobility for Latino/a youth making the consequential transition to adulthood. We propose major expansions to Caminos, an NICHD-funded study collecting 8 time points of data at 6-month lags (2018-2021) for a diverse sample of 547 Latin American-origin adolescents (88% U.S. born) and mothers (80% foreign born) in suburban Atlanta, GA. The proposed study will add five time points of annual data, extending current measures into the transition to adulthood and assessing hair and salivary cortisol indicating chronic and acute stress, waist circumference, and survey reports of chronic disease risk and social mobility. The 13 time points of data (2018 to 2026) will trace the onset of behaviors from as early as age 11 and occurring during a time of important societal changes. We will use state-of-the-art methods to multiply impute intentionally and unintentionally missing data for a cohort of mother-child dyads with high retention in the ongoing study. Guided by family stress models and contextual-developmental theory, cross-lagged path models and latent growth mixture models will test the hypothesis that family, biological, and behavioral health stress processes mediate associations between adversities (e.g., low interpersonal support) and youth’s mental health risks (internalizing and externalizing symptoms, substance use), chronic disease risks (e.g., asthma, diabetes), and social mobility (e.g., educational attainment). Using tests of moderated mediation, we will identify community-, family-, and individual-level protective factors that mitigate impacts of stress on youth outcomes. Sex as a biological variable will be examined as a key modifier. Unique from other national and cohort studies, the proposed research will identify how accumulated adversities shape Latin American-origin youth’s health outcomes and social mobility over time. In addition, the proposed study is uniquely situated to assess factors within and outside of the residential neighborhood, namely, within mothers’ daily activity spaces. Elevating study impacts, findings will inform preventive interventions and programs that can improve health for youth as they prepare for adulthood.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	5	10/19/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $668,812 )
2026	2026	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	5	4/9/2026	NON-COMPETING CONTINUATION	$668,812
2026	2024	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	4	2/13/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $668,812

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	4	5/30/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $665,324 )
2024	2024	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	4	7/11/2024	NON-COMPETING CONTINUATION	$665,324
														Subtotal = $665,324

Issue Date FY: 2023 ( Subtotal = $678,175 )
2023	2023	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	3	5/29/2023	NON-COMPETING CONTINUATION	$678,175
														Subtotal = $678,175

Issue Date FY: 2022 ( Subtotal = $744,007 )
2022	2022	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	2	5/26/2022	NON-COMPETING CONTINUATION	$693,979
2022	2021	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	1	2/24/2022	NEW	$50,028
														Subtotal = $744,007

Issue Date FY: 2021 ( Subtotal = $658,433 )
2021	2021	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	1	9/29/2021	NEW	$0
2021	2021	GEORGE WASHINGTON UNIVERSITY, THE	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	1	9/23/2021	NEW	$658,433
														Subtotal = $658,433

Grand Total All Awards = $3,414,751

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A Longitudinal Study of Adversity, Stress Processes, and Health from Adolescence to Young Adulthood

Award Number: R01HD106650

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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