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NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast

Award Number: R01HD102975
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast - Project Summary/Abstract The NeuroDev Kenya data set will provide an unprecedented opportunity to study the etiology of neurodevelopmental disorders (NDDs) in East Africa, and create a research resource of international value. It will be the first large-scale NDD collection in a rural African setting that is deeply phenotyped and genetically informative, and all data and materials will be made publicly available. In this application, we propose to conduct extensive analysis of NeuroDev Kenya’s genetic and phenotypic data, beginning in the award’s second year. The analyses will leverage the rich environment at KEMRI and will be intertwined with our proposed capacity building activities (Aim 3). Through our capacity building activities, we will provide structured training in genetics and genetic data analysis, determine whether to introduce a lymphoblastic cell line (LCL) protocol into NeuroDev Kenya, and determine how to ethically include adults with ID. We will share all data (e.g. phenotypes, genotypes), and materials (e.g. DNA from blood, possibly LCLs) through the NIH. We will also share outputs through international consortia and a new African NDD Research Network formalized through this award (Aim 4).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $452,522 )
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	001	5	8/29/2025	SUPPLEMENT FOR EXPANSION	$303,306
2025	2025	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	5	8/22/2025	NON-COMPETING CONTINUATION	$149,216
														Subtotal = $452,522

Issue Date FY: 2024 ( Subtotal = $477,536 )
2024	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	4	8/14/2024	NON-COMPETING CONTINUATION	$477,536
														Subtotal = $477,536

Issue Date FY: 2023 ( Subtotal = $516,090 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	3	8/1/2023	NON-COMPETING CONTINUATION	$516,090
														Subtotal = $516,090

Issue Date FY: 2022 ( Subtotal = $542,394 )
2022	2022	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	2	8/24/2022	NON-COMPETING CONTINUATION	$542,394
														Subtotal = $542,394

Issue Date FY: 2021 ( Subtotal = $606,048 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Child Health and Human Development Extramural Research	000	1	9/21/2021	NEW	$606,048
														Subtotal = $606,048

Grand Total All Awards = $2,594,590

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NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast

Award Number: R01HD102975

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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