Sunday, May 11, 2025 5/11/2025

Integrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseases

Award Number: R01HD101669
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Integrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseases - Project Summary/Abstract Gestational duration and birth weight are primary indicators of pregnancy outcomes. They are associated with perinatal morbidity and mortality and also with childhood and adult disorders. In the past several years, we have made substantial progress in the genomic research of gestational duration and birth weight. First, we conducted large-scale genome-wide association (GWA) studies and identified six maternal genomic loci associated with gestational duration, and 190 maternal or fetal loci associated with birth weight. Second, we developed statistical methods to dissect the maternal and fetal genetic effects on birth outcomes. Third, we have studied the causal relationships between maternal phenotypes and birth outcomes as well as the life course associations between birth outcomes and late onset disorders. Despite these successes, there is a major gap in previous genomic studies – they usually targeted either gestational duration or birth weight separately albeit these two birth outcomes are statistically correlated and biologically related. To bridge this gap, we – the leading investigators who previously focused on either gestational duration or birth weight separately – have committed to work together and integrate the genomic research of gestational duration or birth weight. We propose a novel statistical approach to jointly model the maternal and fetal genetic effects on gestational duration and fetal growth. Specifically, we will 1) use birth weight as a surrogate for gestational duration and leverage UK Biobank birth weight data for more powerful GWA discoveries of genomic loci associated with gestational duration; 2) disentangle and replicate maternal and fetal effects by integrated genomic analysis in mother/infant duos; and 3) integrate genomics and phenomics to resolve the complexity of birth outcomes and their links with late onset diseases. These cohesive study aims transcend conventional GWA studies and the results generated from this study will increase our knowledge of the biology of human birth timing and fetal growth. This study also has the potential to inform preventative and therapeutic measures for preterm birth and adverse pregnancy outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $465,743 )
2024	2024	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Child Health and Human Development Extramural Research	000	4	5/1/2024	NON-COMPETING CONTINUATION	$465,743
														Subtotal = $465,743

Issue Date FY: 2023 ( Subtotal = $466,267 )
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Child Health and Human Development Extramural Research	000	3	4/7/2023	NON-COMPETING CONTINUATION	$466,267
														Subtotal = $466,267

Issue Date FY: 2022 ( Subtotal = $544,640 )
2022	2022	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Child Health and Human Development Extramural Research	000	2	6/10/2022	NON-COMPETING CONTINUATION	$544,640
														Subtotal = $544,640

Issue Date FY: 2021 ( Subtotal = $604,168 )
2021	2021	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Child Health and Human Development Extramural Research	000	1	4/27/2021	NEW	$604,168
														Subtotal = $604,168

Grand Total All Awards = $2,080,818

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Integrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseases

Award Number: R01HD101669

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer