Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Effectiveness of Robot-Assisted Hand Movement Training After Stroke

Award Number: R01HD062744
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/12/2010
PERIOD OF PERFORMANCE END DATE: 08/31/2031

Group Awards By:

View Award Description

Effectiveness of Robot-Assisted Hand Movement Training After Stroke - Project Summary/Abstract The broad, long-term, scientific objective of this project is to identify the behavioral and neural factors that determine the efficacy of robotic hand movement training after stroke. An important societal impact of achieving this objective will be the design of more effective rehabilitation exercise technologies, which will allow people with a stroke to increase their movement recovery beyond that possible with current approaches. In a previous grant, participants with impaired finger proprioception (quantified robotically with a novel protocol) did not achieve a functional benefit from robotic finger training. Reduced benefit also correlated with injury to and abnormal activation of the somatosensory system. This was consistent with the working hypothesis that finger proprioceptive integrity is a gateway for robotic assistance because it allows the nervous system to interpret and integrate robotic assistance. A subsequent clinical trial tested whether the putative proprioceptive teaching signal could be improved by tailoring robotic training to target finger proprioceptive deficits. We developed “Propriopixel” training, which replaces select visual gaming elements with robot-generated proprioceptive cues, redirecting attention to proprioceptive input for motor decisions. Among those with finger proprioceptive deficits, Propriopixel Training was significantly more effective than standard robotic training. Proprioception gains occurred only with Propriopixel training and correlated with hand function improvement. This is promising: individuals with impaired proprioception benefited from specialized, sensory-targeting, robotic training, with evidence of improved neural processing of proprioception. The current goal is to understand and improve these results. Aim 1 is to map the dose-response relationship of UE proprioceptive training. To achieve high dose training, this project will supplement lab-based, robotic hand training with home-based practice using a toolbox of innovative mobile Rehab proprioceptive training technologies. Aim 2 is to determine how individuals with more severe hand impairment and/or spatial neglect respond to UE proprioceptive training. In the two previous tests of robotic hand training, individuals with no hand function or spatial neglect were excluded. This project will adapt proprioceptive training techniques to these individuals and quantify the benefits. Aim 3 is to model which proprioceptive processing impairments and improvements predict hand function improvements. This aim will deploy a strategically selected set of proprioceptive and associated EEG assessments during Aim 1 and 2 to identify which baseline features and which changes matter. By achieving these aims, this project will yield fundamental insight into how the hand proprioceptive system adapts with targeted robotic training after stroke, establishing dose-response and mechanistic makers to inform later translational trials. For the many post-stroke individuals living with finger proprioceptive loss, these insights will lay the scientific groundwork needed for a new rehabilitation pathway tailored to them.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	11	10/26/2026	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $339,932 )
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	11	8/25/2026	COMPETING CONTINUATION	$339,932
														Subtotal = $339,932

Issue Date FY: 2024 ( Subtotal = -$18,280 )
2024	2022	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	10	9/19/2024	NON-COMPETING CONTINUATION	-$11,161
2024	2022	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	001	10	9/19/2024	SUPPLEMENT FOR EXPANSION	-$7,119
														Subtotal = -$18,280

Issue Date FY: 2022 ( Subtotal = $487,531 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	000	9	1/21/2022	SUPPLEMENT FOR EXPANSION	$55,842
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	002	9	6/20/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	003	10	6/23/2022	SUPPLEMENT FOR EXPANSION	$134,020
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	001	10	6/14/2022	NON-COMPETING CONTINUATION	$297,669
														Subtotal = $487,531

Issue Date FY: 2021 ( Subtotal = $298,796 )
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	000	9	6/2/2021	NON-COMPETING CONTINUATION	$298,796
														Subtotal = $298,796

Issue Date FY: 2020 ( Subtotal = $305,956 )
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	000	8	5/19/2020	NON-COMPETING CONTINUATION	$305,956
														Subtotal = $305,956

Issue Date FY: 2019 ( Subtotal = $296,413 )
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	000	7	5/3/2019	NON-COMPETING CONTINUATION	$296,413
														Subtotal = $296,413

Issue Date FY: 2018 ( Subtotal = $308,848 )
2018	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Child Health and Human Development Extramural Research	000	6	7/24/2018	COMPETING CONTINUATION	$308,848
														Subtotal = $308,848

Issue Date FY: 2014 ( Subtotal = $289,227 )
2014	2014	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	5	3/8/2014	NON-COMPETING CONTINUATION	$289,227
														Subtotal = $289,227

Issue Date FY: 2013 ( Subtotal = $282,875 )
2013	2013	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	4	1/29/2013	NON-COMPETING CONTINUATION	$268,268
2013	2013	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	001	4	6/10/2013	NON-COMPETING CONTINUATION	$14,607
														Subtotal = $282,875

Issue Date FY: 2012 ( Subtotal = $287,852 )
2012	2012	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	3	3/9/2012	NON-COMPETING CONTINUATION	$287,852
														Subtotal = $287,852

Issue Date FY: 2011 ( Subtotal = $290,537 )
2011	2011	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	2	3/28/2011	NON-COMPETING CONTINUATION	$272,380
2011	2011	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	001	2	7/12/2011	NON-COMPETING CONTINUATION	$18,157
														Subtotal = $290,537

Issue Date FY: 2010 ( Subtotal = $321,433 )
2010	2010	UNIVERSITY OF CALIFORNIA, IRVINE	2301 BERKELEY PLACE	IRVINE	CA	92697	ORANGE	USA	Child Health and Human Development Extramural Research	000	1	3/12/2010	NEW	$321,433
														Subtotal = $321,433

Grand Total All Awards = $3,491,120

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Effectiveness of Robot-Assisted Hand Movement Training After Stroke

Award Number: R01HD062744

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/12/2010

PERIOD OF PERFORMANCE END DATE: 08/31/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer