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High-resolution reconstruction of 3D spatial genome architectures for multi-level biological contexts

Award Number: R01GM169394
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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High-resolution reconstruction of 3D spatial genome architectures for multi-level biological contexts - PROJECT SUMMARY (See instructions): The 3D configurations of DNA folding play pivotal roles in molecular biology and genetics, by providing the multi-scale biophysical foundations to spatially orchestrate different processes and pathways. Remarkably, spatial genome conformations demonstrate complex structural variations across different levels of biological contexts, including diverse cell types, specific genotypes in a population, and distinct species through evolution. Therefore, as a paradigm shift beyond 1D or 2D genome analyses, it is fundamentally important to characterize the context-specific 3D genome structures, especially at high-resolution. However, due to the excessively high rates of missing data and the technical difficulties of profiling Hi-C data for diverse biological contexts, it is strongly desired to develop new mathematical and computational models that can directly reconstruct high-resolution spatial genome structures in the 3D space for different biological contexts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $294,266 )
2026	2026	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 360	EAST LANSING	MI	48824	INGHAM	USA	Biomedical Research and Research Training	000	1	7/16/2026	NEW	$294,266
														Subtotal = $294,266

Grand Total All Awards = $294,266

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High-resolution reconstruction of 3D spatial genome architectures for multi-level biological contexts

Award Number: R01GM169394

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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