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Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel

Award Number: R01GM154105
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 05/31/2028

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Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel - Project Summary Nucleic acid aptamers (aptamers) have been used as therapeutic agents or delivery ligands for various biomedical applications such as regenerative medicine, cancer therapy, molecular biosensing, cell delivery, detoxification, anti-inflammation, anti-coagulation, etc. However, the success of these applications largely depends on the discovery and delivery of high-affinity and high-specificity aptamers, which remains challenging today. Therefore, the objective of this project is to study an innovative method for aptamer selection and truncation, and to further examine the efficiency of in vivo aptamer delivery in regulating inflammation. We will work on four specific aims to achieve the objective. In the first three aims, we will focus on aptamer selection and truncation. Notably, while these three aims are related to one another, the proposed research activities in these aims can be conducted independently. After the selection and truncation of high-quality aptamers, we will examine microneedle-mediated aptamer delivery for local, defined treatment of inflammation using an animal model. The success of this project will not only lead to the development of a technological platform for therapeutic aptamer discovery, but also pave a new way of fighting against inflammatory cytokines in the treatment of complicated immune disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $468,177 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	2	4/21/2025	NON-COMPETING CONTINUATION	$468,177
														Subtotal = $468,177

Issue Date FY: 2024 ( Subtotal = $482,777 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Biomedical Research and Research Training	000	1	8/29/2024	NEW	$482,777
														Subtotal = $482,777

Grand Total All Awards = $950,954

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Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel

Award Number: R01GM154105

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 05/31/2028

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