Friday, September 19, 2025 9/19/2025

Generative neural networks for structure-based antibody design

Award Number: R01GM147893
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/17/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Generative neural networks for structure-based antibody design - PROGRAM SUMMARY/ABSTRACT As a molecular detection platform, antibodies have growing importance in modern medical technology, ranging from diagnostic tests, to imaging, to therapeutics. The current market size for antibodies and their related products is estimated to be around $200 billion USD. The growing need for antibodies with customized specificity provides a rich environment for engineering efforts. Computational protein design has seen rapid progress in recent years. Many methods have been developed to address antibody engineering needs. Researchers have hoped that, through modeling and design, the cost for antibody development and improvements can be reduced and the pace for creating new targeting molecules can be expedited. In recent years, the experimental pipeline has been streamlined, but even so, extensive libraries and screen campaigns are usually required to get an initial binding signal. A major advancement would be to directly design a binder from scratch, providing a signal for potential optimization by artificial evolution. Current computational methods, however, have not taken a leading role due to a number of shortcomings with the current modeling approach. We have extensive expertise in protein design and have pioneered the use of generative neural network models for protein structures in recent years. We have observed several key advantages in neural network approaches over existing methods: namely, their ability to make inferences, interpolate, incorporate topological information, and accelerate sampling. These advantages can be developed independently or used in conjunction with existing methods, and they can significantly boost the performance of protein design. This project aims at leveraging several new advances we have developed to date to inspire new strategies in response to the challenges in antibody engineering, or AI-based protein design in general. We will develop new tools and design pipelines for expanding the specificities for multi- specific antibodies and customizing epitope-specific antibodies (using snake venoms and CXCR4 as targets). This project will deliver both computational methods and constructs that can be deployed in clinical settings. The results from this research will be highly impactful.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $330,540 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	4	8/26/2025	NON-COMPETING CONTINUATION	$330,540
														Subtotal = $330,540

Issue Date FY: 2024 ( Subtotal = $330,540 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	3	8/30/2024	NON-COMPETING CONTINUATION	$330,540
														Subtotal = $330,540

Issue Date FY: 2023 ( Subtotal = $462,285 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	001	2	9/14/2023	NON-COMPETING CONTINUATION	$329,456
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	002	2	9/15/2023	SUPPLEMENT FOR EXPANSION	$132,829
2023	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	1	11/14/2022	NEW	$0
														Subtotal = $462,285

Issue Date FY: 2022 ( Subtotal = $415,987 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Biomedical Research and Research Training	000	1	9/16/2022	NEW	$415,987
														Subtotal = $415,987

Grand Total All Awards = $1,539,352

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Generative neural networks for structure-based antibody design

Award Number: R01GM147893

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/17/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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