Monday, February 16, 2026 2/16/2026

Microfluidics to explore ultrafast cell deformations to deliver large cargo via convective transport

Award Number: R01GM144727
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

Group Awards By:

View Award Description

Microfluidics to explore ultrafast cell deformations to deliver large cargo via convective transport - Project Summary The delivery of molecules and particles to cells is important for increased scientific understanding of molecular processes and networks, detecting intracellular biomarkers in diagnostic targets, and genetic modification of therapeutic cells. The challenges associated with current delivery approaches include limits to the size of molecules that can be delivered (especially plasmid DNA), damage or modification to target cells, and a limit to the cell processing throughput. In studies to develop new methods that can be used to deliver molecules and particles more broadly to many cell types, a novel cellular behavior was discovered that occurs as cells are rapidly compressed at timescales faster than a millisecond. As a result of fast compressions upon cells, cells respond by a temporary change of volume, which results in a pressure driven flow across the cell membrane to restore cell volume, and as a byproduct carries extracellular reagents into a cell through a convective phenomenon. The goal of this study is to understand how to optimize devices exploiting a new biophysical regime of cell compression in which fast timescales (<1 millisecond), high strain (>30%) to impact cells. These physical impacts of cells are increasingly important to understand due to applications in lab on a chip, cell sorting, and cell engineering. Secondly, the microfluidic technology will be optimized and tested for microfluidic delivery of probes and labels, as well as transfection of large transgenes for a variety of important cell types. The understanding of cell mechanical responses in an unexplored region of time and magnitude could enable new approaches to label and reprogram the cell that will be efficient to a broad range of cell types and reagents.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $300,833 )
2025	2025	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	4	8/26/2025	NON-COMPETING CONTINUATION	$300,833
														Subtotal = $300,833

Issue Date FY: 2024 ( Subtotal = $300,999 )
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Biomedical Research and Research Training	000	3	8/19/2024	NON-COMPETING CONTINUATION	$300,999
														Subtotal = $300,999

Issue Date FY: 2023 ( Subtotal = $300,999 )
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	2	8/18/2023	NON-COMPETING CONTINUATION	$300,999
														Subtotal = $300,999

Issue Date FY: 2022 ( Subtotal = $300,999 )
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	1	9/20/2022	NEW	$300,999
														Subtotal = $300,999

Grand Total All Awards = $1,203,830

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Microfluidics to explore ultrafast cell deformations to deliver large cargo via convective transport

Award Number: R01GM144727

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer