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?Conus venom peptides and their molecular targets: Using pharmaconomics and neuroethology as a framework for discovery?

Award Number: R01GM144719
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract The hundreds of different bioactive components in the venoms of cone snails have demonstrated extraordinary biomedical potential in the past, including development as an FDA-approved drug. However, their discovery and characterization is generally limited by the small amounts of venom that are accessible. Our laboratory has developed a calcium-imaging platform combined with selective pharmacology (“Constellation Pharmacology”), that when combined with recent technical advances in transcriptomic and proteomic analysis and electrophysiology (an integrated platform that we call Pharmaconomics) completely changes the landscape with respect to discovery and characterization of novel venom components. Using pharmaconomics, one goal is to tightly couple the discovery and biochemical characterization of individual venom components with the elucidation of the molecular and cellular mechanisms that underlie their biological activity. The pharmaconomics approach also uncovers how individual components affect physiology at the system’s and whole animal level. We will use the insights gained from the characterization of bioactive venom components to rationalize the species-specific behavior and neuroethology of the cone snail and it’s fish prey. These new tools should allow an unprecedented rate of discovery of novel bioactive cone snail venom components tightly linked to the elucidation of their molecular targets. Although the focus of this project is on venom peptides and their molecular targets, the pharmaconomics approach can be used for elucidating the physiologically-relevant molecular target of any natural product. Linking the vast chemical diversity of natural products to their cognate macromolecular receptors should greatly expand the use of natural products as pharmacological tools in basic research, as well as their therapeutic and other biomedical applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $517,563 )
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	3	2/13/2024	NON-COMPETING CONTINUATION	$517,563
														Subtotal = $517,563

Issue Date FY: 2023 ( Subtotal = $738,634 )
2023	2023	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	2	2/7/2023	NON-COMPETING CONTINUATION	$574,453
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	001	2	5/16/2023	SUPPLEMENT FOR EXPANSION	$10,811
2023	2023	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	002	2	5/30/2023	SUPPLEMENT FOR EXPANSION	$153,370
														Subtotal = $738,634

Issue Date FY: 2022 ( Subtotal = $573,218 )
2022	2022	UNIVERSITY OF UTAH, THE	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Biomedical Research and Research Training	000	1	3/15/2022	NEW	$573,218
														Subtotal = $573,218

Grand Total All Awards = $1,829,415

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?Conus venom peptides and their molecular targets: Using pharmaconomics and neuroethology as a framework for discovery?

Award Number: R01GM144719

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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