Monday, February 16, 2026 2/16/2026

The role of microtubule dynamics in midzone driven chromosome segregation in anaphase

Award Number: R01GM144668
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/03/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2027

Group Awards By:

View Award Description

The role of microtubule dynamics in midzone driven chromosome segregation in anaphase - Summary The faithful segregation of chromosomes during mitosis is a fundamental and important process, happening approximately a quadrillion time throughout a human life span. Errors in mitosis have severe implications and are often detrimental to development, health and survival of the organism. Microtubules are the main building blocks of mitotic spindles and are a very important target for cancer therapy. We know that microtubules, in particular kinetochore microtubules, exert forces on chromosomes to initially position them on the metaphase plate and consequently divide them to the two daughter cells. However, recent research has shown that the central spindle also plays an important role in chromosome segregation. The precise mechanisms of how the central spindle regulates chromosome segregation are not fully understood today. A line of evidence has suggested that the central spindle can generate outward pushing forces to move chromosomes, but it has also been convincingly shown to slow chromosome segregation down by acting like a break. The goal of this proposal is to dissect the function of the central spindle during anaphase and to identify how the central spindle generates forces contributing to the segregation of chromosomes. We further aim to establish the contribution of microtubule dynamics for central spindle function. To achieve this goal, we use the microstructural data from tomography in wild type and mutant conditions to monitor the microtubule arrangement and properties in the central spindle during anaphase and to identify potential interactions and force generating mechanisms. We will complement the precise structural data with dynamic data on microtubules in the midzone obtained by cutting edge light-microscopic analysis. We will use mathematical modeling to develop and test hypothesis of how the spindle midzone contributes to chromosome segregation in anaphase. The ultimate goal of our study is to understand how the central spindle generates forces that regulate the segregation of chromosomes and to identify the molecular key players of this process


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $326,883 )
2026	2026	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	5	1/28/2026	SUPPLEMENT FOR EXPANSION	$25,227
2026	2026	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	5	1/27/2026	NON-COMPETING CONTINUATION	$301,656
														Subtotal = $326,883

Issue Date FY: 2025 ( Subtotal = $410,853 )
2025	2025	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	4	8/12/2025	NON-COMPETING CONTINUATION	$33,517
2025	2025	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	4	1/15/2025	NON-COMPETING CONTINUATION	$301,656
2025	2025	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	4	1/16/2025	SUPPLEMENT FOR EXPANSION	$75,680
														Subtotal = $410,853

Issue Date FY: 2024 ( Subtotal = $385,626 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	3	6/21/2024	SUPPLEMENT FOR EXPANSION	$50,453
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	3	1/10/2024	NON-COMPETING CONTINUATION	$301,656
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	3	6/24/2024	NON-COMPETING CONTINUATION	$33,517
														Subtotal = $385,626

Issue Date FY: 2023 ( Subtotal = $542,173 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	2	1/12/2023	NON-COMPETING CONTINUATION	$301,656
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	001	2	3/29/2023	NON-COMPETING CONTINUATION	$33,517
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	002	2	5/17/2023	SUPPLEMENT FOR EXPANSION	$207,000
														Subtotal = $542,173

Issue Date FY: 2022 ( Subtotal = $335,173 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Biomedical Research and Research Training	000	1	2/3/2022	NEW	$335,173
														Subtotal = $335,173

Grand Total All Awards = $2,000,708

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The role of microtubule dynamics in midzone driven chromosome segregation in anaphase

Award Number: R01GM144668

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/03/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer