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Cellular basis of complex social behavior

Award Number: R01GM144560
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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Cellular basis of complex social behavior - Summary/Abstract A broad goal for biologists is to understand how genetic variation influences phenotype, including development, physiology, and disease. For complex behaviors, it remains difficult to trace a path from the genome to particular cell populations to brain function. In the proposed research, we will identify how natural variation in vertebrate social behavior is encoded within the genome and executed in the brain via context dependent gene expression in specific cell types. To accomplish this, we will utilize the assemblage of cichlids from Lake Malawi, East Africa to take advantage of recent evolutionary radiation that generated large differences in social behavior with minimal genetic divergence. We will use new automated methods to quantify differences in male bower building behavior. We will map forebrain cell types recruited during bower building and identify cis-regulatory circuits in these brain regions, using RNA-seq and ATAC-seq from single cells. Finally, we will use QTL mapping and the construction of near-isogenic lines (NILs) to identify the genetic basis of bower behavior and link genome regions to specific behavioral and cellular subroutines. This work will identify cell populations, gene expression programs and neuronal circuits regulating social behaviors in outbred vertebrates and provide comparative insights into human behavioral diversity including common neurological diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $361,809 )
2023	2023	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	2	7/28/2023	NON-COMPETING CONTINUATION	$361,809
														Subtotal = $361,809

Issue Date FY: 2022 ( Subtotal = $361,496 )
2022	2022	GEORGIA TECH RESEARCH CORPORATION	926 DALNEY ST NW	ATLANTA	GA	30332	FULTON	USA	Biomedical Research and Research Training	000	1	9/9/2022	NEW	$361,496
														Subtotal = $361,496

Grand Total All Awards = $723,305

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Cellular basis of complex social behavior

Award Number: R01GM144560

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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