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A Network Science Approach to Conflicts of Interest: Metrics, Policies, and Communication Design

Award Number: R01GM141476
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/2020
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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A Network Science Approach to Conflicts of Interest: Metrics, Policies, and Communication Design - The primary purpose of this project is to develop new metrics and mechanisms for the evaluation of conflicts of interest (COI) risks in the biomedical research enterprise. The innovation in COI risk evaluation and communication will draw on a shift away from the conceptualization of COI as a problem of individual researchers toward an understanding of COI as network phenomena. The pressing problems of COI and the bias it inculcates stem not from individuals but from the aggregation of COI across networks of researchers and funders. The research team will leverage machine-learning and high performance computing to (1) track the circulation of COI within biomedical decision networks, and (2) evaluate the extent to which certain conflict network profiles predict increased risks of patient harm. The team will test candidate COI metrics with U.S. Food and Drug Administration's Adverse Events Reporting System drug safety data. Using these data as a foundation, this project will also (3) develop and evaluate strategies for communicating COI risks of bias designed to safeguard against the perverse outcomes in current disclosure practices. The results of this research will underwrite novel evidence-based recommendations for COI policies in biomedical research as well as recommendations for more effective disclosure practices. To achieve these aims, this project will leverage machine-learning to identify systemic COI networks within the biomedical research enterprises for specific drug products. The research team will then evaluate to what extent network metrics predict relative increases in adverse event rates and severity for identified products.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $203,871 )
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	001	4	6/18/2024	NON-COMPETING CONTINUATION	$20,386
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	000	4	11/20/2023	NON-COMPETING CONTINUATION	$183,485
														Subtotal = $203,871

Issue Date FY: 2023 ( Subtotal = $204,301 )
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	001	3	4/5/2023	NON-COMPETING CONTINUATION	$20,429
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	000	3	11/21/2022	NON-COMPETING CONTINUATION	$183,872
														Subtotal = $204,301

Issue Date FY: 2022 ( Subtotal = $208,172 )
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	001	2	6/23/2022	NON-COMPETING CONTINUATION	$20,817
2022	2022	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	000	2	11/29/2021	NON-COMPETING CONTINUATION	$187,355
														Subtotal = $208,172

Issue Date FY: 2021 ( Subtotal = $215,960 )
2021	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Biomedical Research and Research Training	000	1	11/24/2020	NEW	$215,960
														Subtotal = $215,960

Grand Total All Awards = $832,304

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A Network Science Approach to Conflicts of Interest: Metrics, Policies, and Communication Design

Award Number: R01GM141476

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/2020

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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