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Regulation of Voltage-gated Proton Channel

Award Number: R01GM139991
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/08/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Regulation of Voltage-gated Proton Channel - Abstract The voltage-gated Hv1 proton channel is a member of voltage-gated ion channel family, it plays a key role in the acid extrusion from excitable and non-excitable cells and regulate pH homeostasis in a variety of cell types. The Hv1 proton channel provides charge and pH compensation during the respiratory burst of the phagocyte NADPH oxidase and controls production of reactive oxygen species in phagocytes, it mediates proton efflux at the pulmonary alveolar cell membrane and acidifies excessively alkaline airway surface liquid in the airway cells. Hv1 is found to be a sperm flagellar regulator of intracellular pH, and play a crucial role in sperm capacitation. In addition, Hv1 activity is required for acid extrusion to shape action potentials in snail neurons. Studies have shown that biophysical properties and functions of the Hv1 channel are not identical in a variety of tissues, the distinct manifestations of native voltage-gated proton channels in different cell types indicate the existence of modulatory partners modulating the Hv1 proton channel's function. We recently identified a family of transmembrane protein as the Hv1 channel interactor. We discovered that the presence of the transmembrane protein alters the Hv1 channel's activity and modulates the channel's voltage-dependent gating. The goal of this proposal is designed to determine the effects of the transmembrane protein on the Hv1 channel physiology, biophysics, and pharmacology. The proposed research will establish the physiological relevance of Hv1 channel regulation by transmembrane modulators and shed light on novel voltage-gated ion channel regulatory mechanisms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $287,820 )
2025	2025	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	000	5	1/15/2025	NON-COMPETING CONTINUATION	$287,820
														Subtotal = $287,820

Issue Date FY: 2024 ( Subtotal = $319,800 )
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	001	4	6/11/2024	NON-COMPETING CONTINUATION	$31,980
2024	2024	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	000	4	1/17/2024	NON-COMPETING CONTINUATION	$287,820
														Subtotal = $319,800

Issue Date FY: 2023 ( Subtotal = $319,800 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	000	3	1/18/2023	NON-COMPETING CONTINUATION	$287,820
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	001	3	2/16/2023	NON-COMPETING CONTINUATION	$31,980
														Subtotal = $319,800

Issue Date FY: 2022 ( Subtotal = $319,800 )
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	000	2	2/7/2022	NON-COMPETING CONTINUATION	$287,820
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	001	2	6/27/2022	NON-COMPETING CONTINUATION	$31,980
														Subtotal = $319,800

Issue Date FY: 2021 ( Subtotal = $319,800 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Biomedical Research and Research Training	000	1	2/5/2021	NEW	$319,800
														Subtotal = $319,800

Grand Total All Awards = $1,567,020

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Regulation of Voltage-gated Proton Channel

Award Number: R01GM139991

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/08/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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