Tuesday, July 1, 2025 7/1/2025

Chemical Probes to Study Methionine Redox Biology

Award Number: R01GM139245
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2028

Group Awards By:

View Award Description

Chemical Probes to Study Methionine Redox Biology - Project Summary/Abstract Protein methionine residues are emerging as essential redox sites for physiological processes spanning signal transduction, antioxidant defense, and regulation of protein function. At the same time, aberrant elevations in methionine oxidation induced by oxidative stress and/or inactivation of methionine sulfoxide reductase enzymes can contribute to cancer, neurodegenerative and vascular diseases, and life span. To decipher contributions of methionine redox physiology and pathology, we are developing new chemical reagents to selectively label reactive methionine sites from proteins to proteomes. The scientific premise is that providing access to a modular chemical toolbox for methionine bioconjugation will help unveil new functional methionine sites in proteins to further understanding of physiological and pathological contributions through covalent methionine tagging. Selective methionine bioconjugation using redox-based probes that emulate the innate oxidative chemistry of these residues offers chemical innovation, while demonstrating scientific rigor through the combined use of diverse synthetic, modeling, proteomic, and biochemical approaches to provide general tools for probing the reactive methionine landscape. Specifically, we seek to (1) design robust and highly specific oxaziridine probes by establishing a predictive model for tuning selectivity and stability of methionine adducts, (2) identify proteome-wide oxidatively-sensitive methionine sites and analyze motifs to reveal principles of methionine hyperreactivity, and (3) biochemically characterize targets involved in reversible redox regulation, with a particular focus on cancer-dependent targets where methionine oxidation can influence cellular metabolism.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $454,156 )
2025	2025	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	006	7	6/13/2025	NON-COMPETING CONTINUATION	$428,340
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	002	5	4/17/2025	COMPETING CONTINUATION	-$413,294
2025	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	005	6	5/20/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$81,192
2025	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Biomedical Research and Research Training	003	6	4/18/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$439,110
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	004	5	5/20/2025	COMPETING CONTINUATION	-$81,192
2025	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	5	1/17/2025	COMPETING CONTINUATION	$81,191
2025	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	4	1/17/2025	NON-COMPETING CONTINUATION	-$81,191
														Subtotal = $454,156

Issue Date FY: 2024 ( Subtotal = $413,295 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	5	4/12/2024	COMPETING CONTINUATION	$413,295
														Subtotal = $413,295

Issue Date FY: 2023 ( Subtotal = $378,375 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	4	6/12/2023	NON-COMPETING CONTINUATION	$378,375
														Subtotal = $378,375

Issue Date FY: 2022 ( Subtotal = $381,177 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	3	6/22/2022	NON-COMPETING CONTINUATION	$381,177
														Subtotal = $381,177

Issue Date FY: 2021 ( Subtotal = $473,334 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	001	2	7/16/2021	SUPPLEMENT FOR EXPANSION	$89,622
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	2	5/11/2021	NON-COMPETING CONTINUATION	$383,712
														Subtotal = $473,334

Issue Date FY: 2020 ( Subtotal = $383,295 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Biomedical Research and Research Training	000	1	6/16/2020	NEW	$383,295
														Subtotal = $383,295

Grand Total All Awards = $2,483,632

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Chemical Probes to Study Methionine Redox Biology

Award Number: R01GM139245

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer