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Post-transcriptional mechanisms of centrosome regulation

Award Number: R01GM138544
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Post-transcriptional mechanisms of centrosome regulation - Project Summary Centrosome deregulation is the leading cause of heritable microcephaly, a congenital birth defect typically associated with intellectual disabilities and developmental delay. Centrosome dysfunction is also considered a key driver and prognostic marker of cancer. Yet, mechanisms underlying centrosome regulation remain incompletely understood. Centrosomes undergo cell cycle-dependent changes in composition and organization to modulate their activity as microtubule-organizing centers, and these oscillations contribute to the diversity of centrosome functions. One dynamic constituent of centrosomes is mRNA, yet the functional role of mRNA localized to centrosomes remains poorly understood. In this proposal, we examine whether mRNA contributes to centrosome regulation and functions. In Aim 1, we define mechanisms of mRNA localization to centrosomes. In Aim 2, we uncover the regulatory contributions of two conserved RNA-binding proteins. Aim 3 examines the function of mRNA localized to centrosomes. The completion of this work will address long- standing questions about the role of mRNA localized to centrosomes within a genetically tractable model. This work will contribute to our understanding of centrosome regulation, aspects of which are deregulated in cases of microcephaly and cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $340,780 )
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	001	4	6/25/2024	SUPPLEMENT FOR EXPANSION	$2,200
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	003	5	8/23/2024	SUPPLEMENT FOR EXPANSION	$15,555
2024	2024	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	002	5	6/25/2024	NON-COMPETING CONTINUATION	$323,025
2024	2023	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	000	4	4/8/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $340,780

Issue Date FY: 2023 ( Subtotal = $462,091 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	001	4	6/29/2023	SUPPLEMENT FOR EXPANSION	$64,547
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	002	4	6/30/2023	SUPPLEMENT FOR EXPANSION	$74,103
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	000	4	6/28/2023	NON-COMPETING CONTINUATION	$323,441
														Subtotal = $462,091

Issue Date FY: 2022 ( Subtotal = $342,599 )
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	001	3	7/19/2022	SUPPLEMENT FOR EXPANSION	$18,780
2022	2022	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	000	3	6/17/2022	NON-COMPETING CONTINUATION	$323,819
														Subtotal = $342,599

Issue Date FY: 2021 ( Subtotal = $337,423 )
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	000	1	6/14/2021	SUPPLEMENT FOR EXPANSION	$13,260
2021	2021	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	001	2	6/24/2021	NON-COMPETING CONTINUATION	$324,163
														Subtotal = $337,423

Issue Date FY: 2020 ( Subtotal = $324,476 )
2020	2020	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	Biomedical Research and Research Training	000	1	7/22/2020	NEW	$324,476
														Subtotal = $324,476

Grand Total All Awards = $1,807,369

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Post-transcriptional mechanisms of centrosome regulation

Award Number: R01GM138544

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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