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Substrate targeting mechanism of a DesCEND pathway

Award Number: R01GM135592
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2020
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Substrate targeting mechanism of a DesCEND pathway - Abstract This request for a supplement to the grant R01GM135592 proposes the acquisition of an automated high- throughput crystallization screening system to support the research aims that focus on investigating the substrate targeting mechanisms of the F-box subunit FBXO31 of the SCF ubiquitin ligase in a novel DesCEND pathway. By identifying and characterizing substrates of FBXO31 at both a systems level and the molecular level, we proposed to elucidate the complementary structural determinants of the FBXO31–degron pair that confer substrate specificity and dictate protein recognition and fate. To achieve our goals, it is vital that we have the ability to screen wide ranges of crystallization conditions that are essential for obtaining high resolution protein- substrate complex structures. This proposal requests funds to replace a 10-year old Gryphon-100ul Flex instrument with a similar but up-to-date version from the same manufacturer. In addition to having reputable performance quality, the proposed system covers a broad range of screening applications and meets the automation requirements needed to develop a streamlined approach for crystallization in a high-throughput fashion. We have obtained institutional support from the Department of Molecular Biology and Biophysics. The instrument will ensure the continued biochemical, biophysical and structural studies proposed in the parent award.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Biomedical Research and Research Training	001	4	6/17/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Biomedical Research and Research Training	000	4	6/17/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $473,656 )
2023	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Biomedical Research and Research Training	000	4	5/19/2023	NON-COMPETING CONTINUATION	$421,706
2023	2023	UNIVERSITY OF CONNECTICUT HEALTH CENTER	263 FARMINGTON AVE	FARMINGTON	CT	06030	CAPITOL	USA	Biomedical Research and Research Training	001	4	8/10/2023	SUPPLEMENT FOR EXPANSION	$51,950
														Subtotal = $473,656

Issue Date FY: 2022 ( Subtotal = $432,410 )
2022	2022	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Biomedical Research and Research Training	000	3	5/18/2022	NON-COMPETING CONTINUATION	$432,410
														Subtotal = $432,410

Issue Date FY: 2021 ( Subtotal = $513,000 )
2021	2021	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Biomedical Research and Research Training	001	2	7/9/2021	SUPPLEMENT FOR EXPANSION	$70,340
2021	2021	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Biomedical Research and Research Training	000	2	5/19/2021	NON-COMPETING CONTINUATION	$442,660
														Subtotal = $513,000

Issue Date FY: 2020 ( Subtotal = $468,682 )
2020	2020	UNIVERSITY OF CONNECTICUT	263 FARMINGTON AVE, ASB #3	FARMINGTON	CT	06032	CAPITOL	USA	Biomedical Research and Research Training	000	1	8/13/2020	NEW	$468,682
														Subtotal = $468,682

Grand Total All Awards = $1,887,748

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Substrate targeting mechanism of a DesCEND pathway

Award Number: R01GM135592

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2020

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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