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Physiological Role for Cation Channels in Bacteria

Award Number: R01GM132436
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Physiological Role for Cation Channels in Bacteria - SUMMARY Tetrameric cation channels are widely conserved among all species. While bacterial cation channels are often used in structural and biophysical assays as models for their eukaryotic homologs, little is known about their physiological role in bacteria. Escherichia coli (E. coli) possesses a single tetrameric K+ channel, kch, which bears high sequence homology to eukaryotic K+ channels. The generation of a viable ∆kch strain created as part of a large E. coli single-gene knockout collection led to kch being categorized as a non-essential protein, and the functional role of this putative K+ channel has remained unknown. Preliminary data demonstrates that Kch is actually an essential protein and that ∆kch strains acquire suppressor mutations in order to remain viable. These suppressor mutations provide important clues as to which metabolic processes utilize the channel and has revealed a potential physiological role for Kch. Based on these results, the following aims are proposed: (1) to characterize the functional properties of the kch K+ channel; (2) to determine how Kch function affects E. coli physiology; and (3) to expand these findings to other bacteria to elucidate the conserved functions of bacterial cation channels. The results of this work will expand knowledge on the role of cation channels in bacterial physiology. Given the prevalence of these channels in pathogenic bacteria, understanding how cation channels benefit them may reveal how these proteins could be exploited as novel drug targets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$113 )
2026	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	4	3/12/2026	NON-COMPETING CONTINUATION	-$113
														Subtotal = -$113

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	4	6/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $385,971 )
2022	2022	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	001	4	6/22/2022	NON-COMPETING CONTINUATION	$385,971
2022	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	3	10/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $385,971

Issue Date FY: 2021 ( Subtotal = $385,971 )
2021	2021	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	3	6/29/2021	NON-COMPETING CONTINUATION	$385,971
														Subtotal = $385,971

Issue Date FY: 2020 ( Subtotal = $385,457 )
2020	2020	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	2	6/19/2020	NON-COMPETING CONTINUATION	$385,457
														Subtotal = $385,457

Issue Date FY: 2019 ( Subtotal = $394,808 )
2019	2019	TEXAS A & M UNIVERSITY	400 HARVEY MITCHELL PKY S STE 300	COLLEGE STATION	TX	77845	BRAZOS	USA	Biomedical Research and Research Training	000	1	6/12/2019	NEW	$394,808
														Subtotal = $394,808

Grand Total All Awards = $1,552,094

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Physiological Role for Cation Channels in Bacteria

Award Number: R01GM132436

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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